10368 results for 'GDF-5/BMP-14'

ST2 and IL33

ST2, a member of the IL-1R Subfamily ST2 is a member of the IL-1R subfamily and was identified in 1989 [1]. The ST2 gene is located on chromos ...

HERV-K group of endogenous retroviruses and cancer

In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germ ...

p38 MAPK Signaling Review

The p38 MAPK signaling pathway is an intracellular signaling pathway that plays a crucial role in cellular responses to various stressors and inflammatory stimuli. It is a part of the larger MAPK ...

3D Organoid Cell Viability Assay: Performance Assessment in Human Colon Organoids

The 3D Organoid Cell Viability Assay (AKES081) demonstrated high sensitivity and low cytotoxicity, making it ideal for long incubation studies (24-48 hours) and high-throughput applicat ...

CD27 Activation: Strengthening the Immune Army Against Cancer

Harnessing the immune system to fight cancer has become a pivotal strategy in modern oncology. A key component in this fight is CD27, a receptor that plays a crucial role in T-cell activ ...

Boiling Proteins for Western Blotting: Optimal Conditions and Best Practices

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Epigenetic modifiication & Histone methylation

Agata Miezaniec PhD Candidate, University of Nottingham, UK Epigenetics and the link to DNA Methylation The term ‘Epigene ...

Sandwich ELISA: Step-by-Step Protocol & Troubleshooting

Written by Seán Mac Fhearraigh, PhD • Updated: 19 May 2026 • ~10 min read Quick Answer A sandwich ELISA uses two antib ...

ILC2: The Immune Cell That Fights Allergies and Infections

ILC2 - Function, Cytokines, and Role in Health and Disease A quick guide to IL2C ...

Freezing Stimulated T Cells: A Detailed Guide

Cryopreservation of stimulated T cells is a common technique in immunology research, allowing for long-term storage while maintaining their functional viability. Stimulated T cells—espec ...

RIPA Buffer Recipe - Cell Lysis | Assay Genie

RIPA (Radio Immuno Precipitation Assay) buffer is mostly used when carrying out a western blot or immunoprecipatation assay. A RIPA buffer is used in order to lyse cells and extract protein fr ...

Innate Viral Immunity & RIG-I in COVID-19

RIG-I: Antiviral Properties in COVID-19 (SARS-CoV-2) Infection Key Points RIG-I is a cytosolic RNA ...

Heterogeneity of Type 1 diabetes in children

Ahmad Gazali PhD candidate, University of Eastern Finland Type 1 diabetes (T1D) is an autoimmune disease where the pancreatic β cells that produce insulin, a key hormone involve ...

Cell Synchronisation Methods

What is Cell Synchronisation? Cell synchronisation is a process by which cells at different stages of the cell cycle in a culture are brought to the same phase. Cell synchronisation is ...

Physiological Roles for IL-33 | Assay Genie

By Charlotte O'Donnell PhD A role for IL-33 in Barrier Function and Epithelial Wound Healing ...

Passaging Hybridoma Cells: A Detailed Guide

Hybridoma cells are essential tools for producing monoclonal antibodies and are derived by fusing B lymphocytes (antibody-producing cells) with myeloma cells (cancer cells) to achieve bo ...

Flow Cytometry Protocol | 10 Hints & Tips

Flow Cytometry Protocol The meaning is in the name: Flow = in motion, Cyto = cells, Metry = measure. What is Flow Cytometry? Flow c ...

Transformation Protocol – Sample Transformation Protocols

Introduction Transformation of bacteria with plasmids is not only of note for bacterial studies but also can be used for gene expression studies in mammalian cells. Most plasmids are of bac ...

Metabolism or pluripotency – which regulates which? A chicken or the egg story.

By Sophie Arthur How many diseases and conditions do you think exist in this world? Thousands? Hundreds of thousands? Maybe even millions? Unfortunately, I don’t know the answer. But what ...

Early Diagnosis is key: Pick the weed or allow it destroy the garden?

By Catríona Dowling, Post-Doc, RCSI I want you to come on a journey with me where we are going to the botanic gardens. You will pick a section of the garden that is yours: yours to treasure ...

CD4+ T Cells: Unveiling the Role of Helper and Regulatory T Cells

CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Help ...

The double-edged sword in prostate cancer therapy

By Zoe Angel, PhD Student, Ulster University Prostate cancer is now the commonest cancer in men and it is the fifth leading cause of death (1). Researc ...

Assay Genie launch SARS-CoV-2 qPCR assay

SARS-CoV-2 qPCR assay from Assay Genie Assay Genie have just launched a qPCR assay for the detection of SARS-CoV-2. The SARS-CoV-2 One-Step RT-qPCR Kit for Cor ...

ELISA vs Western Blot: Which Technique Should You Choose?

Written by Seán Mac Fhearraigh, PhD • Updated: 19 May 2026 • ~9 min read Quick Answer ELISA and Western Blot are both antibody-based protein detection methods. ELISA is f ...

10 Steps of Glycolysis: Enzymes, Diagram & ATP Yield

Innate Lymphoid Cells Differentiation: Guardians of Immune Homeostasis

Innate Lymphoid Cells (ILCs) represent a fascinating component of the immune system, playing a crucial role in maintaining tissue homeostasis and mounting rapid responses against pathogens. Th ...

Autophagy in Focus: Molecular Mechanisms and Functional Insights

Autophagy, a fundamental cellular process, plays an indispensable role in maintaining cellular homeostasis and ensuring the efficient recycling of cellular components. Through this ...

Fluorescence spectroscopy: An early detection tool for cancer.

Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early unders ...

What is RNAi? All You Need to Know

Guide to Bacterial Transformation: The Science of Genetic Manipulation

3D Organoid Cell Viability Assay: Assessing Environmental Stress on BENOs for Live Delivery

3D Organoid Cell Viability Assay (AKES081) effectively measures BENO model viability across different storage conditions. AKES081 detects significant viability differences, particularly ...

Guide to Western Blot Sample Preparation

Western blotting remains a pivotal technique in the molecular biosciences for the detection, quantification, and analysis of proteins. Its utility spans numerous fields, including immunology, de ...

Non-Small Cell Lung Carcinoma: Understanding, Diagnosing, and Treating NSCLC

Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer, representing about 85% of all lung cancer cases. NSCLC includes several subtypes, with distinct biological c ...

Decoding the Language of Cells: Chemokine Signaling Pathways Unveiled

Chemokines are small signaling proteins that play a crucial role in the immune system by directing the movement of cells, orchestrating immune responses, and maintaining tissue homeostasis. Th ...

Bevacizumab: Mechanism, Clinical Applications, and Biosimilar Insights

Quick Facts About BevacizumabWhat is Bevacizumab?Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF), inhibiting angiogenesis (the formation of n ...

Serum vs Plasma: Key Differences & When to Use Each [Guide]

Blood plasma and serum are essential components of blood and have distinct molecular compositions and uses in the medical and research fields. This article aims to elucidate the differences betwe ...

Tigatuzumab: Advancing Cancer Research with Targeted Therapies

Quick Facts About TigatuzumabWhat is Tigatuzumab?Tigatuzumab is a monoclonal antibody that targets the death receptor 5 (DR5) pathway, inducing apoptosis in cancer cells.What is the mec ...

NRF2 Signaling: A Keystone in Inflammation and Disease Management

Nuclear Factor Erythroid 2–Related Factor 2 (NRF2) orchestrates a principal defense mechanism against oxidative stress and plays a pivotal role in inflammation and disease pathogenesis. This arti ...

Immunoglobulin vs Antibody: Unveiling the Intricacies

In the realm of immunology, the terms "immunoglobulin" and "antibody" often find themselves used interchangeably, sparking confusion among those keen on understanding the immune system's fine det ...

Understanding Blotchy Western Blots: Causes and Remedies

Western blotting is a powerful and widely used technique in molecular biology, essential for detecting and quantifying specific proteins in complex biological samples. However, despite its pop ...

STING Activators As Cancer Therapeutics

The STING (Stimulator of Interferon Genes) pathway plays a pivotal role in the innate immune system's response to cancerous cells and DNA viruses. Exploiting this pathway through STING activators ...

Promising COVID-19 Therapeutics

SARS-CoV-2, the causative viral agent of the novel coronavirus disease COVID-19, has sparked a global effort for creating prophylactic and therapeutic interventions. The following ...

SfN Neuroscience 2024

SfN 2024: Meet Assay Genie at the Society for NeuroscienceAssay Genie is delighted to be attending SfN 2024 in Chicago, Illinois on 5th to the 9th of October at the McCormick Convention ...

The Rat Effectively Models Signature Cytokines of T Helper Cells

Understanding the immune system's intricacies requires models that accurately reflect its complexity. The rat, as a model organism, plays a crucial role in immunological research, particularly i ...

COVID-19 Vaccine Candidates

What is COVID-19 COVID-19, the disease caused by the coronavirus named SARS-CoV-2, first identified in Wuhan, China in December 2019 has spr ...

Unlocking Cellular Adaptation: The HIF Enhancer Pathway and Its Implications in Hypoxia Response

Hypoxia, or low oxygen levels, poses a significant challenge to cells, necessitating rapid and efficient adaptation mechanisms. The Hypoxia-Inducible Factor (HIF) pathway is a well-known regul ...

Clinical Pathology Labs List: Overview, Services, and Importance

Clinical pathology labs play a crucial role in modern healthcare, providing critical diagnostic testing services for a wide array of diseases and conditions. These laboratories are desig ...

Converting RPM to G-force in Centrifugation

Centrifuges play a pivotal role in scientific research and various industries, enabling efficient separation and isolation of components within a sample. Understanding the relations ...

Mesenchymal Stem Cells: Navigating the Frontiers of Regenerative Medicine

Mesenchymal stem cells (MSCs) have emerged as pivotal players in the realm of regenerative medicine due to their unique properties and versatile potential. Originally discovered in the bone marro ...

Scientific Illustrations by Science Picture Co

SciencePicture.Co— Scientific & Medical Illustration About SciencePicture.Co is a science and med ...

Top 10 Universities in the UK

Before I even started my PhD I was already thinking about carrying out PostDoc in a foreign country and had my sights set on going to the US. I had previously carried out a degree in Genetic ...

Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer

Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Pancreatic can ...

Types of ELISA: Direct, Indirect, Sandwich & Competitive Compared

Written by Seán Mac Fhearraigh, PhD • Updated: 19 May 2026 • ~9 min read Quick Answer The five main types of ELISA are sandwich, competitive, direct, indirect and multiple ...

TLX as a Novel Therapeutic Target

Danka Kozareva PhD Candidate, University College Cork The generation of neurons from stem cells The process of generating ...

PhD Interview tips

It’s not uncommon now for Masters or Undergraduate students to present some data or data that they produced during their research for a PhD interview process. Sometimes this can be in front of ...

The Brain's Sentinels: How Microglia Shape Neuroinflammation in Disease

The Brain's Sentinels: How Microglia Shape Neuroinflammation in Disease In the intricate landscape of the human brain, a silent, ever-watchful guardian stands ready to defend against injury and inva ...

How does Acute Myeloid Leukaemia start?

I have been in the situation that I’m sure many of us have. I work on genes, which if you name to any right-minded individual, sound like a random string of nonsensical gibberish. So, mayb ...

How to be a Confident Speaker (Scientific)

Like needles in a haystack, interesting speakers that bring charisma and rock n roll to their talks are hard to come by. No matter what the research interests of the audience, these speakers h ...

BTLA: A Key Player in Immune Regulation and Cancer Therapy

Introduction to BTLA in Immune Regulation B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that plays a critical role in regulating immune responses by suppress ...

The Ebola Virus: What You Need to Know

The Ebola virus has been in the news a lot lately, but many people still don't know what it is or how it spreads. In this blog post, we will discuss the basics of the Ebola virus: w ...

Cancer Research Club March 2020

ELISA Genie is delighted to announce the date of our next Cancer Research Club which will be taking place on the 31st of March at TTMI, Trinity College Dublin. This event will foc ...

TA Cloning

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Privacy Policy

Reagent Genie Website privacy notice Privacy Notice This is the privacy notice of Reagent Genie Limited. In this document, “we”, “ou ...

Urea Assays

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Molecular Biology

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RIPA Buffer Recipe

What is RIPA Buffer? RIPA (Radio Immuno Precipitation Assay) buffer is primarily used when conducting a western blot or immunoprecipatation assay. A RIPA buffer is used in order to l ...

Immunohistochemistry (IHC) Buffers & Recipes

What is IHC? Immunohistochemistry (IHC) is a valuable tool used for the identification of specific antigens within embedded tissue prepara ...

Mouse Multiplex Inflammation ELISA Panels

The ELISA Genie, Mouse inflammation multiplex assays utilizes multiple bead populations differentiated by size and different levels of fluorescence intensity. With multiple sizes of bea ...

DNA Assembly Cloning

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High-Fidelity DNA Polymerase

What is DNA Polymerase Fidelity? The fidelity of a DNA polymerase is the result of accurate replication of a desired template. The fidelity of DNA polymerase ...

Mycoplasma Testing - Detection & Elimination

Mycoplasma Testing Mycoplasma Detection & Elimination Kits Visually detect Mycoplasma by eye in 1 hour! View Validation h1.page-heading{ display: ...

Western Blot Sample Protocol - Mandarin

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COVID-19 Cytokine Storm Multiplex Assays

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T4 DNA Ligase

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Top 10 Therapeutics

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In Vivo Antibody Sampler Packs

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RIPA Buffer Recipe - Mandarin

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Site Directed Mutagenesis

Key Takeaways: Site-directed mutagenesis (SDM) enables precise DNA sequence alterations. Used for investigating protein activity changes and introducing beneficial mutations. GenieClone ki ...

IHC Buffers & Recipes - Mandarin

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Sistema di Trasporto Virale con MTM – Tampone Faringeo Generico

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Non-Human Primate Multiplex ELISA Panels

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Lipid Metabolism Assays

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Chemokines

Chemokines Key Research Areas C Chemokine Ligands XCL1/Lymphot ...

Subcellular Fractionation Protocol - Mandarin

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Western Blot Buffers & Recipes - Mandarin

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Beta Actin Monoclonal Antibody

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COVID-19 Swab Test

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Liver & Kidney Biomarker Assays

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CD4+ T-helper cell differentiation

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Ferroptosis Assays

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Glucose Uptake Assay Kits

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About Us

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Distributors

At Assay Genie, we're proud to support scientists in acheiving their research goals around the globe! Working with the right distributors is an important part of achieving our mission. C ...

Tunel 1-Step Assay Kits

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Cell Culture Guide - Techniques and Protocols - Mandarin

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Co-Immunoprecipitation (co-IP) Protocol - Mandarin

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Interactive Pathway Diagrams

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Adipocytokines

Adipocytokines or adipokines are bioactive molecules that are produced by adipose tissue. They comprise cytokines, chemokines coagulation factors and factors involved ...

Transcription Factor Activity Assay Kits

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COVID-19 Throat Swab Test

COVID-19 Throat Swab Test Throat/Oropharyngeal Swabs for Viral Sample Collection The development of diagnostic tests for COVID- ...