10424 results for 'TGF-beta RI/ALK-5'

Transforming Growth Factor-Beta (TGF-β) signaling pathway plays a pivotal role in orchestrating various cellular processes, ranging from embryonic development to tissue homeostasis and immun ...

Understanding Beta-Oxidation: A Comprehensive Overview Fatty acids provide a highly efficient energy storage mechanism, delivering more energy per gram than common carbohydrates like glu ...

Growth factors play a vital role in the complex web of biological processes, serving as key regulators in various essential events. They exert significant influence over cruc ...

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor epidermal growth factor receptor (EGFR) which triggers ligand-induced ...

Introduction Tumorigenesis, the process by which normal cells transform into cancer cells, is a multifaceted and complex event influenced by various internal and external factors. Among th ...

Imagine engineering a patient's own immune cells into precision-guided missiles against cancer—cells that can seek out and destroy tumors with remarkable specificity. This is the promise of CAR-T cel ...

What is a Macrophage? Macrophages are indeed a type of phagocyte, responsible for engulfing and destroying foreign particles and cellular debris. They are larger cells with more cytoplasm a ...

Th17 cells, a subset of T helper cells characterized by their production of interleukin-17 (IL-17), play a significant role in the immune system's response to pathogens and in the pathology of a ...

Interleukin signaling is involved in a number of biological processes, including cell growth and differentiation, inflammation and immunity. Interleukins are glycoproteins which act on hem ...

What are Stem Cells? Stem cells are primitive, undifferentiated, and unspecialised cells that are found in multicellular organism ...

Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer, representing about 85% of all lung cancer cases. NSCLC includes several subtypes, with distinct biological c ...

In the intricate ballet of cellular communication and regulation, growth factors play pivotal roles in guiding the processes of cell growth, division, and differentiation. These proteins are esse ...

Quick Facts About AbituzumabWhat is Abituzumab?Abituzumab is a monoclonal antibody that targets αv-integrins, playing a role in cancer treatment and fibrotic diseases.What is the mechan ...

Understanding the immune system's intricacies requires models that accurately reflect its complexity. The rat, as a model organism, plays a crucial role in immunological research, particularly i ...

Key Points Non-alcoholic fatty liver disease (NAF ...

by Ryan Wallis, PhD student, QMUL, Blizard Institute The microscopic world of cell biology was first explored by Robert Hooke in the 17th century and published in his work, Microgr ...

PhD Summit - A Virtual Conference ELISA Genie is proud to announce the launch of a groundbreaking virtual conference - PhD Sum ...

What is the Coronavirus Spike Protein? COVID-19, the newest coronavirus to gain international attention, is caused by severe acute respirato ...

T Cell Types, Activation, Polarization & Function A comprehensive guide to T cells! window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); wi ...

Antigen's are foreign molecules recognised by the immune system. Antigens can be protein, carbohydrate, lipid or nucleic acid molecules. Examples include viruses and bacteria as well as f ...

CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Help ...

Toll-Like Receptors The innate immune response has come under the spotlight in recent years due to its central role in propagating the pathoge ...

Interleukin 12 in COVID-19 Prophylactics Interleukin 12 is a cytokine with wide-reaching effects in the innate and adaptive immune system. O ...

Overview of Diabetes Mellitus Diabetes mellitus (DM) is a major epidemic that affects over 347 million people worldwide (Danaei et al. 2011). The World He ...

Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...

Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis (IPF) is a chronic, irreversible and ultimately fatal disease characterized by pro ...

Regulatory T cells (Tregs) play a crucial role in maintaining immune balance by suppressing excessive immune responses that could lead to tissue damage. However, in the context of cancer ...

Explore the complexities of Interleukin-10 (IL-10) signaling and regulation, a crucial aspect in immune response modulation and its dual roles in cancer development and therapy. Key Takeaways ...

Quick Facts About AducanumabWhat is Aducanumab?Aducanumab is a monoclonal antibody designed to target and reduce amyloid-beta plaques in the brain, a hallmark of Alzheimer’s disease.Wha ...

Hepatocellular carcinoma (HCC) is one of the most frequently occurring cancers and there are 630,000 new cases diagnosed every year worldwide (De Minicis et al. 2013). HCC develops frequently f ...

Immunoglobulins (Igs), also known as antibodies, are glycoproteins produced by B cells and plasma cells. They play a central role in the immune system by identifying and neutralizing pat ...

By Charlotte O’Donnell PhD Inflammation and Cancer The link between inflammation and cancer is well established, with inf ...

Discover the critical role of cytokines as signaling molecules in immune responses, their functions, and the impact of their dysregulation, including cytokine storms. Key Takeaways: C ...

Understanding PIIINP Levels in Canine Liver FibrosisLiver fibrosis is a significant health concern in dogs, often leading to severe complications if not diagnosed and managed appropriately. This arti ...

By Diana-Madalina Stan, PhD student, University of Salford Disease Description Alzheimer’s disease (AD), the most common cause of dementia, is ...

By Charlotte O’Donnell PhD Cancer Carcinogenesis is a multi-step process that develops through epigenetic changes an ...

Imagine a microscopic sniper, capable of delivering a lethal blow to a single cancer cell while leaving its healthy neighbors virtually untouched. This is the promise of targeted alpha therapy, a re ...

CXCL16 CXCL16, a unique member of the CXC chemokine family, stands at the crossroads of immune modulation and vascular biology. Initially discovered as a che ...

The human body is a complex and intricate system where various components work together to maintain health and combat potential threats. Among these essential players are the TNF cy ...

Testing for COVID-19 Since the start of the COVID-19 pandemic, the World Health Organisation have emphasised the crucial impor ...

Natural killer (NK) cells are a crucial component of the innate immune system and play a significant role in eliminating tumor cells. Unlike T cells, NK cells can recognize and kill canc ...

Understanding Myeloid Cell Networks in Cancer ImmunotherapyImmunotherapy has revolutionized cancer treatment, yet its effectiveness in re-establishing original immune responses post-therapy remains l ...

Delving into TNF alpha's critical role in inflammation and its therapeutic targeting. Key Takeaways: TNF alpha is a crucial cytokine in inflammation and apoptosis. Its structure facilita ...

Exploring sepsis: a critical imbalance in the immune response to infection. Key Takeaways: Sepsis is a severe, immune-driven response to infection causing systemic inflammation and poten ...

Alzheimer's disease stands as a formidable challenge in the realm of neurological disorders, characterized by its progressive nature and profound impact on cognitive functions. This article delv ...

What does the COVID-19 Rapid POC CE-IVD Test detect? The test detects the presence of patient-generated antibodies against spike protein, the virus which causes the disease COVID-19. The te ...

BDNF Overview Brain-derived neurotrophic factor (BDNF) is a central mediator of neuroplasticity, a term used to describe the ability of neuron ...

Inflammasomes are complex intracellular structures that play a pivotal role in the immune response by detecting pathogenic microorganisms and sterile stressors. Their activation is a critical ste ...

RIPA (Radio Immuno Precipitation Assay) buffer is mostly used when carrying out a western blot or immunoprecipatation assay. A RIPA buffer is used in order to lyse cells and extract protein fr ...

Introduction to FoxP3 and Regulatory T Cells in CancerFoxP3 (forkhead box P3) is a transcription factor critical for the development and function of regulatory T cells (Tregs), a special ...

اختبار COVID-19 POC السريع الوصف إن مجموعة الفحص الجيني تستخدم فقط COVID-19 Rapid POC ( ...

Bone Morphogenetic Proteins (BMP) were first discovered in the 1960s by Dr.Marshall Urist, an orthopaedic surgeon at UCLA (Urist 1965). BMPs are classically associated with their roles in limb ...

Fenofibrate, also known as FEN, is a drug that is used to lower cholesterol levels. It works by blocking the absorption of dietary cholesterol in the small intestine and therefore, re ...

Complete T Helper Cell Guide: Th1, Th2, Th17 & Functions - Your Ultimate Resource from Assay GenieIn this guide, we will explore the differences between TH1 and TH2 cells, their cruc ...

Descripción Para más información, por favor, contacte a hello@assaygenie.com El kit Assay Genie u ...

Adhesion Molecules Direct cell-cell interactions are maintained and regulated by cell adhesion molecules. The expression of adhesion molecule ...

Mechanical forces are common in biological systems and dominate numerous perturbations that are relevant to human physiology and disease. Mechanobiology is a new field that evaluates the ef ...

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Quick Facts About CanakinumabWhat is Canakinumab?Canakinumab is a human monoclonal antibody that targets interleukin-1 beta (IL-1β), reducing inflammation associated with various diseas ...

As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progression as well as biomarkers from atherosclerosis related d ...

Exploring the multifaceted role of dendritic cells in immune function and disease. Key Takeaways DCs are professional antigen-presenting cells that capture, process, and pres ...

The choice of appropriate cell culture supplements emerges as a crucial factor in ensuring the efficacy and consistency of experimental results. Among the various options available, two common ...

Introduction Microtubules are key components of the cytoskeleton and are composed of alpha and beta tubulin. These dimerise in a head to tail fashion to form 13 linear protofilaments.

By Charlotte O'Donnell PhD Similar to IL-33, IL-36R ligands are involved in maintaining intestinal homeostasis. Analogous to IL-33, d is local ...

Kinases, key enzymes in cellular signaling, phosphorylate proteins to regulate crucial processes, and their modulation has significant implications in disease treatment. Key Takeaways: K ...

In the intricate tapestry of the immune system, macrophages play a pivotal role, orchestrating a wide range of biological responses that protect the body against pathogens, remove cellular debris ...

The 2025 Nobel Prize in Physiology or Medicine has been awarded to a trio of scientists for their groundbreaking work on peripheral immune tolerance, a mechanism that prevents our immune system from ...

Antibodies are a special class of Y shaped proteins that help guard your body from invading viruses and bacteria. They do this by either neutralizing the dangerous substance ...

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ELISA Sampler Packs Based on thousands of citations and years of scientific endeavour, Assay Genie has developed ELISA Sampler Packs. An ELISA Sampler Pack is a ...

Adipocytokines or adipokines are bioactive molecules that are produced by adipose tissue. They comprise cytokines, chemokines coagulation factors and factors involved ...

PharmaGenie ELISA Validated According to ISO Quality Systems Highly validated ELISA designed to exceed the needs of biopharma R&D s ...

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Cell-Based ELISA Kits No More Western Blots! Over 1,600 Cell-Based ELISA kits to measure the relative levels of intracellular and phosphorylat ...

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    Chemokines   Key Research Areas       C Chemokine Ligands XCL1/Lymphot ...

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Loading Control Antibodies High Performing Loading Control Antibodies Explore Loading Control Antibodies window.SHOGUN_IMAGE_ELEMENTS = w ...

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Transcription Factor Assays Detect Transcription Factors via indirect ELISA methods! Detect transcription factors or study transcription fact ...

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ELISpot 400x more sensitive than ELISA! Detection & Visualisation at the Single-Cell Level Explore ELISpot ...

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What is IHC? Immunohistochemistry (IHC) is a valuable tool used for the identification of specific antigens within embedded tissue prepara ...

High Sensitivity Cytokine ELISA Cytokine ELISA Kits & Multiplex ...

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Co-stimulatory and Co-inhibitory Molecules in Adaptive Immunity The adaptive immune system is in part regulated by a vast array of co-stim ...

Animal DIY ELISA Kits Maximise your research budget! Animal DIY (Do-It-Yourself) ELISA kits are sets of reagents to develop your very own san ...

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What is RIPA Buffer? RIPA (Radio Immuno Precipitation Assay) buffer is primarily used when conducting a western blot or immunoprecipatation assay. A RIPA buffer is used in order to l ...

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