RPA2 Rabbit Polyclonal Antibody (CAB2189)
- SKU:
- CAB2189
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | RPA2 Rabbit Polyclonal Antibody |
SKU: | CAB2189 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-270 of human RPA2 (NP_002937.1). |
Sequence: | IRHA EKAP TNIV YKID DMTA APMD VRQW VDTD DTSS ENTV VPPE TYVK VAGH LRSF QNKK SLVA FKIM PLED MNEF TTHI LEVI NAHM VLSK ANSQ PSAG RAPI SNPG MSEA GNFG GNSF MPAN GLTV AQNQ VLNL IKAC PRPE GLNF QDLK NQLK HMSV SSIK QAVD FLSN EGHI YSTV DDDH FKST DAE |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | REPA2; RPA32; RP-A p32; RP-A p34; RPA2 |
Positive Sample: | 293T,293T+UV,NIH/3T3,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, PML body. |
Calculated MW: | 29kDa |
Observed MW: | 32kDa |
This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways.
Purification Method: | Affinity purification |
Gene ID: | 6118 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |