STAG3 Antibody (PACO56366)
- SKU:
- PACO56366
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | STAG3 Antibody (PACO56366) |
| Antibody SKU: | PACO56366 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cohesin subunit SA-3 protein (1056-1212AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO56366 diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO56366 diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. |
| Synonyms: | Cohesin subunit SA-3 (SCC3 homolog 3) (Stromal antigen 3) (Stromalin-3), STAG3 |
| UniProt Protein Function: | STAG3: Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 7q22.1Cellular Component: chromosome, pericentric region; extracellular space; nucleus; synaptonemal complexBiological Process: synaptonemal complex assemblyDisease: Premature Ovarian Failure 8 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q9UJ98 |
| NCBI GenInfo Identifier: | 68847235 |
| NCBI Gene ID: | 10734 |
| NCBI Accession: | Q9UJ98.2 |
| UniProt Secondary Accession: | Q9UJ98,Q8NDP3, A6H8Z1, B4DZ10, D6W5U8, H7BYK9 |
| UniProt Related Accession: | Q9UJ98 |
| Molecular Weight: | 132,319 Da |
| NCBI Full Name: | Cohesin subunit SA-3 |
| NCBI Synonym Full Names: | stromal antigen 3 |
| NCBI Official Symbol: | STAG3Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | cohesin subunit SA-3 |
| UniProt Protein Name: | Cohesin subunit SA-3 |
| UniProt Synonym Protein Names: | SCC3 homolog 3; Stromal antigen 3; Stromalin-3 |
| Protein Family: | STAG3-like protein |
| UniProt Gene Name: | STAG3Â Â |
| UniProt Entry Name: | STAG3_HUMAN |
| Antibodies |
| STAG3 Antibody (PACO02361) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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