Anti-ELOVL1 Antibody (PACO16253)

Antibody Name:	ELOVL1 Antibody (PACO16253)
Antibody SKU:	PACO16253
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human ELOVL1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16253(ELOVL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16253(ELOVL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).

Background:

Elongation of very long chain fatty acid, like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acid, and sphingolipids. The ELOVL proteins act as catalysts in fatty acid, elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long chain fatty acid, protein 1 (ELOVL1), also referred to as Ssc1, is the human homolog of the yeast ELO3 protein. It is expressed in a variety of tissues and at especially high levels in stomach, skin, intestine, kidney and lung. ELOVL1 participates in the elongation of very long chain saturated and monounsaturated fatty acid, of up to 26 carbons and may be required for the development of a barrier in epithelial cells and skin. ELOVL1 is also important for the formation of Myelin in the central nervous system. Impaired ELOVL1 activity may be associated with disorders of sphingolipid metabolism.

Synonyms:

ELOVL fatty acid, elongase 1

UniProt Protein Function:	ELOVL1: Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Belongs to the ELO family.
UniProt Protein Details:	Protein type:EC 2.3.1.199; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p34.2 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane Molecular Function:fatty acid elongase activity; protein binding Biological Process: fatty acid elongation, saturated fatty acid; linoleic acid metabolic process; sphingolipid biosynthetic process; very-long-chain fatty acid biosynthetic process
UniProt Code:	Q9BW60
NCBI GenInfo Identifier:	20137931
NCBI Gene ID:	64834
NCBI Accession:	Q9BW60.1
UniProt Secondary Accession:	Q9BW60,Q53HT2, Q5JUY3, Q8WXU3, Q9NVD9, Q9Y396, B4DP24
UniProt Related Accession:	Q9BW60
Molecular Weight:	29,485 Da
NCBI Full Name:	Elongation of very long chain fatty acids protein 1
NCBI Synonym Full Names:	ELOVL fatty acid elongase 1
NCBI Official Symbol:	ELOVL1
NCBI Official Synonym Symbols:	Ssc1; CGI-88
NCBI Protein Information:	elongation of very long chain fatty acids protein 1
UniProt Protein Name:	Elongation of very long chain fatty acids protein 1
UniProt Synonym Protein Names:	3-keto acyl-CoA synthase ELOVL1
Protein Family:	Elongation of very long chain fatty acids protein
UniProt Gene Name:	ELOVL1
UniProt Entry Name:	ELOV1_HUMAN

Antibodies	ELISA Kits
ELOVL1 Antibody (PACO00755)	Human Elongation of very long chain fatty acids protein 1 / ELOVL1 ELISA Kit
	Human Elongation of very long chain fatty acids protein 1 (ELOVL1) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)