Anti-FGF20 Antibody (PACO19659)

Antibody Name:	FGF20 Antibody (PACO19659)
Antibody SKU:	PACO19659
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human FGF20

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19659(FGF20 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility.

Synonyms:

fibroblast growth factor 20

UniProt Protein Function:	FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family.
UniProt Protein Details:	Protein type:Cytokine Chromosomal Location of Human Ortholog: 8p22 Cellular Component: extracellular region Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; signal transduction Disease: Renal Hypodysplasia/aplasia 2
NCBI Summary:	The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]
UniProt Code:	Q9NP95
NCBI GenInfo Identifier:	13626702
NCBI Gene ID:	26281
NCBI Accession:	Q9NP95.1
UniProt Secondary Accession:	Q9NP95,B2RPH5,
UniProt Related Accession:	Q9NP95
Molecular Weight:	23,499 Da
NCBI Full Name:	Fibroblast growth factor 20
NCBI Synonym Full Names:	fibroblast growth factor 20
NCBI Official Symbol:	FGF20
NCBI Official Synonym Symbols:	RHDA2; FGF-20
NCBI Protein Information:	fibroblast growth factor 20
UniProt Protein Name:	Fibroblast growth factor 20
Protein Family:	Fibroblast growth factor
UniProt Gene Name:	FGF20
UniProt Entry Name:	FGF20_HUMAN

Antibodies	ELISA Kits
FGF20 Antibody (PACO01892)	Human FGF20 / Fibroblast growth factor 20 ELISA Kit
	Human Fibroblast growth factor 20 (FGF20) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)