Human BMP 2 Protein Recombinant Protein (RPPB0092)
- SKU:
- RPPB0092
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P12643
- Research Area:
- Cytokines
Frequently bought together:
Description
| Product Name: | Human BMP 2 Protein Recombinant Protein |
| Product Code: | RPPB0092 |
| Size: | 10µg |
| Species: | Human |
| Target: | BMP 2 Protein |
| Synonyms: | BMP-2, BMP2A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | BMP2 was lyophilized from a concentrated (1mg/ml) sterile solution containing 10mM sodium citrate pH=3.5. |
| Solubility: | It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-2 in sterile 20mM AcOH (acetic Acid) not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Bone Morphogenetic Protein-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR |
| Biological Activity: | The ED50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 cells is 0.5-1.0 �g/ml. |
BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.
Bone Morphogenetic Protein-2 Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing 2x115 amino acids and having a molecular mass of 26kDa. The BMP-2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). |
| NCBI Summary: | The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12643 |
| NCBI GenInfo Identifier: | 115068 |
| NCBI Gene ID: | 650 |
| NCBI Accession: | P12643.1 |
| UniProt Related Accession: | P12643 |
| Molecular Weight: | |
| NCBI Full Name: | Bone morphogenetic protein 2 |
| NCBI Synonym Full Names: | bone morphogenetic protein 2 |
| NCBI Official Symbol: | BMP2�� |
| NCBI Official Synonym Symbols: | BDA2; BMP2A�� |
| NCBI Protein Information: | bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A |
| UniProt Protein Name: | Bone morphogenetic protein 2 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 2A; BMP-2A |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP2�� |
| UniProt Entry Name: | BMP2_HUMAN |
