Anti-LAMA1 Antibody (PACO18157)

Antibody Name:	LAMA1 Antibody (PACO18157)
Antibody SKU:	PACO18157
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human LAMA1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18157(LAMA1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18157(LAMA1 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Synonyms:

laminin, α 1

UniProt Protein Function:	LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 18p11.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; laminin-1 complex; laminin-3 complex; extracellular region; basement membrane; intercellular junction Molecular Function:protein binding; extracellular matrix structural constituent; glycosphingolipid binding; receptor binding Biological Process: regulation of cell adhesion; axon guidance; extracellular matrix organization and biogenesis; cell surface receptor linked signal transduction; regulation of embryonic development; morphogenesis of an epithelial sheet; establishment of epithelial cell polarity; cell adhesion; regulation of cell migration Disease: Poretti-boltshauser Syndrome
NCBI Summary:	This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
UniProt Code:	P25391
NCBI GenInfo Identifier:	38788416
NCBI Gene ID:	284217
NCBI Accession:	NP_005550.2
UniProt Related Accession:	P25391
Molecular Weight:	337,084 Da
NCBI Full Name:	laminin subunit alpha-1
NCBI Synonym Full Names:	laminin, alpha 1
NCBI Official Symbol:	LAMA1
NCBI Official Synonym Symbols:	LAMA; PTBHS; S-LAM-alpha
NCBI Protein Information:	laminin subunit alpha-1; S-LAM alpha; S-laminin subunit alpha; laminin A chain; laminin-3 subunit alpha
UniProt Protein Name:	Laminin subunit alpha-1
UniProt Synonym Protein Names:	Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha
Protein Family:	Laminin
UniProt Gene Name:	LAMA1
UniProt Entry Name:	LAMA1_HUMAN

Antibodies	ELISA Kits
LAMA1 Antibody (PACO03931)	Human Laminin subunit alpha-1 / LAMA1 ELISA Kit
	Human Laminin subunit alpha-1 (LAMA1) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)