PD-L1/CD274 Rabbit Polyclonal Antibody (CAB11273)
- SKU:
- CAB11273
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | PD-L1/CD274 Rabbit Polyclonal Antibody |
SKU: | CAB11273 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 19-238 of human PD-L1/CD274 (NP_054862.1). |
Sequence: | FTVT VPKD LYVV EYGS NMTI ECKF PVEK QLDL AALI VYWE MEDK NIIQ FVHG EEDL KVQH SSYR QRAR LLKD QLSL GNAA LQIT DVKL QDAG VYRC MISY GGAD YKRI TVKV NAPY NKIN QRIL VVDP VTSE HELT CQAE GYPK AEVI WTSS DHQV LSGK TTTT NSKR EEKL FNVT STLR INTT TNEI FYCT FRRL DPEE NHTA ELVI PELP LAHP PNER |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 |
Synonyms: | B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1; PD-L1/CD274 |
Positive Sample: | A-549,Mouse skeletal muscle,Rat skeletal muscle |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endomembrane system, Single-pass type I membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 40-50kDa |
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 29126 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |