null

Rat TGFBR1 Recombinant Protein (His tag)

SKU:
RPES5899
Product Type:
Recombinant Protein
Species:
Rat
$179
Frequently bought together:

Description

Product Name:Rat TGFBR1 Recombinant Protein (His tag)
Product Code:RPES5899
Size:20µg
Species:Rat
Expression Host:E.coli
Synonyms:AAT5, Activin receptor like kinase 5, ACVRLK4, ALK-5, LDS1A, LDS2A, MSSE, SKR4, TbetaR I, TGF-beta receptor type-1, TGFBR1, Transforming growth factor beta receptor 1
Mol Mass:20.9 kDa
AP Mol Mass:28 kDa
Tag:N-His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:Please contact us for more information.
Bio Activity:Testing in progress
Sequence:Leu 311-Met 501
Accession:P80204
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor, originally known as ALK-5 (Activin receptor‑like kinase) is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.

Related Products