null

Human AGER/RAGE Recombinant Protein (RPES2165)

SKU:
RPES2165
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology
$235
Frequently bought together:

Description

system_update_altDatasheet

Human AGER/RAGE Recombinant Protein

Advanced Glycosylation End Product-Specific Receptor (AGER) belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.