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Human TNFRSF1B/CD120b Recombinant Protein (RPES4098)

SKU:
RPES4098
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Death
$283
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Description

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Human TNFRSF1B/CD120b Recombinant Protein

Tumor necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction; and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis; which suggests that it regulates TNF-alpha function by antagonizing its biological activity.