9034 results for 'DNA glycosylase'

Imagine a world where we can fold the very fabric of life into microscopic machines, guiding the growth of a single neuron with the precision of a master architect. This isn't science fiction; it is ...

Kit di Estrazione DNA/RNA Virus Il Kit di Estrazione dell'Acido Nucleico Virale II è stato progettato specificamente per la purificazione efficiente del DNA virale e dell'RNA vir ...

Exploring DNA's essence, this guide illuminates its structure, function, and purification techniques, essential in fields like medicine and biotechnology. Key Takeaways: DNA's Struc ...

Imagine a future where a simple blood test could detect cancer in its earliest stages, long before symptoms appear. This isn't science fiction; it's the rapidly advancing reality of liquid biopsy, a ...

Agata Miezaniec PhD Candidate, University of Nottingham, UK Epigenetics and the link to DNA Methylation The term ‘Epigene ...

PCR stands as a cornerstone in molecular biology, enabling scientists to magnify and analyze fragments of DNA with incredible precision. In this blog, we'll embark on understanding of PCR – fro ...

Bacterial transformation, a cornerstone of genetic manipulation, enables DNA insertion into bacterial cells, crucial for advances in vaccine development, drug discovery, and biotechno ...

Unregulated cell growthCancer, although heterogeneous by its very nature, can be broadly defined as a set of diseases characterised by unregulated cell growth leading to invasion of surroundin ...

p53, encoded by the TP53 gene on chromosome 17, is a fundamental protein safeguarding against tumor formation. It orchestrates cellular responses to DNA damage and stress, crucially managing cell ...

Testing for COVID-19 Since the start of the COVID-19 pandemic, the World Health Organisation have emphasised the crucial impor ...

Introduction Transformation of bacteria with plasmids is not only of note for bacterial studies but also can be used for gene expression studies in mammalian cells. Most plasmids are of bac ...

What is COVID-19 COVID-19, the disease caused by the coronavirus named SARS-CoV-2, first identified in Wuhan, China in December 2019 has spr ...

What is Xeroderma Pigmentosum? Xeroderma pigmentosum (XP) also known De Sanctis-Cacchione syndrome is a rare genetic disorder that affects the skin, eyes and central nervous system. It is c ...

The focus of this article is Tumor Suppressor Genes. There are various different types of tumor suppressor genes, with BRCA being one of the most popular. The role of Tumor Suppressor Genes in Ca ...

In the realm of molecular biology and biochemistry, gel electrophoresis stands as a cornerstone technique for the separation and analysis of macromolecules such as DNA, RNA, and proteins. Central ...

Transfection protocols play a crucial role in the realm of molecular biology and genetic research, enabling the introduction of foreign nucleic acids into living cells. This innovat ...

TUNEL Staining : The method of choice for measuring cell death In this article we will discuss everything you need to know about the TUNEL staining assay. We'll start by explaining wha ...

A new way to deliver genetic therapies is making waves in the medical world. The lenti virus vector system has been shown to be more effective than traditional methods of gene thera ...

What is a vaccine? A vaccine is a pharmacological product that gives the recieving patient's immune system a chance to learn how to fight infection with decreased risk of illness. Vacc ...

HMGB1 Functional Overview High mobility group box 1 ( HMGB1), a member of the high-mobility group (HMG) family, was first identified in the thymus in 1973 a ...

Ubiquitin is a small, highly conserved protein found in eukaryotic cells that plays a crucial role in regulating various cellular processes. The process of ubiquitination involves the covalent at ...

HIV Virus: Replication Cycle and Pathogenesis in absence of HAART The human immunodeficiency virus (HIV) is a formidable pathogen that has posed a significant global ...

Rapid Antibody & Antigen tests available from Assay Genie ...

The intricate process of stem cell differentiation and self-renewal is a cornerstone of developmental biology and regenerative medicine. At the heart of this complex regulatory mechanism are tran ...

Inflammasomes are complex intracellular structures that play a pivotal role in the immune response by detecting pathogenic microorganisms and sterile stressors. Their activation is a critical ste ...

The MycoGenie Rapid Mycoplasma Detection Kit enables the detection of 28 Mycoplasma species in under 1 hour using a simple visual determination method, eliminating the need for expensiv ...

Stephen Reynolds, PhD Student, CERVIVA and Trinity College Dublin We hear almost daily now how everyone in their lifetime will be touched by cancer either directly or through a close f ...

The CRISPR-Cas9 system is a powerful tool for genome editing, enabling precise modifications to DNA. The typical CRISPR-Cas9 workflow involves several steps, from designing guide RNAs to ...

Key Points Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a method of gene editing that uses ...

RNA interference (RNAi), also referred to as Post-Transcriptional Gene Silencing (PTGS), is the process by which RNA molecules silence genes in response to double-stranded RNA. RNA interference ( ...

As a PhD student delving deep into the realm of cellular biology, there is one antagonist that consistently challenges my research: mycoplasma. This microscopic bacterium, with its ...

In the realm of molecular biology and genetic engineering, the ability to deliver genetic material into cells is fundamental for various research and therapeutic purposes. Two common methods e ...

Hantavirus, a silent threat lurking in rodent populations, has long posed a significant public health challenge with its severe and often fatal outcomes. For decades, the quest for effective vaccine ...

Novel Gene Therapies for Cystic Fibrosis Cystic Fibrosis Cystic fibrosis (CF) is an autosomal recessive, life-limiting disease resulting from gene mutations that encode the cystic fib ...

Apoptosis Unveiled: Your Complete Guide to Intrinsic & Extrinsic PathwaysAt Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis!K ...

At Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis! Key Takeaways: Apoptosis is a programmed cell death process, vital for tissu ...

by Ryan Wallis, PhD Aging and Disease Imagine a world where everything you do is missing just a little piece and as time goes on you start to lose sense entirely. This is the dev ...

Cancer detection often relies on advanced imaging or invasive procedures, frequently catching the disease at later, more challenging stages. Imagine a future where a simple, non-invasive test could ...

The STING (Stimulator of Interferon Genes) pathway plays a pivotal role in the innate immune system's response to cancerous cells and DNA viruses. Exploiting this pathway through STING activators ...

Oxidative Stress Definition Oxidative stress is a condition that results when the body produces or consumes more reactive oxygen species (ROS) than it can neutrali ...

Platinum based cancer drugs Despite nearly 50% of all anti-cancer treatments being platinum-based, there is an urgent need to develop novel therapeutics ...

Shelly Pathak PhD candidate, University of Leeds SAIDs Systemic Auto-inflammatory diseases (SAIDs) have been defined as a group of mainly inherited disorde ...

What is preeclampsia? According to the World Health Organization (WHO), one in ten pregnant women is affected by hypertensive disorders, and preeclampsia ...

Quick Facts About Rovalpituzumab TesirineWhat is Rovalpituzumab Tesirine?Rovalpituzumab Tesirine (Rova-T) is an antibody-drug conjugate (ADC) designed to target DLL3, a protein overexpr ...

What is Cell Synchronisation? Cell synchronisation is a process by which cells at different stages of the cell cycle in a culture are brought to the same phase. Cell synchronisation is ...

Introduction to MAPK Signaling in Cellular Processes Mitogen-Activated Protein Kinase (MAPK) signaling pathways are crucial in transmitting signals from the cell surface to the DNA in the c ...

Flow Cytometry Protocol The meaning is in the name: Flow = in motion, Cyto = cells, Metry = measure. What is Flow Cytometry? Flow c ...

Delving into the intricate world of Mitotic Catastrophe, this blog unveils its critical role in cell division and cancer therapy, offering insights into its mechanisms and potential treatments ...

Apoptosis, or programmed cell death, is a fundamental process that plays a critical role in the development and maintenance of healthy tissues. Central to this process are caspases, a family of c ...

Introduction Cellular senescence is a fascinating phenomenon that plays a crucial role in the aging process and various age-related diseases. It is essential to explore the cellular ...

Key Facts About GemtuzumabWhat is Gemtuzumab?Gemtuzumab is an antibody-drug conjugate (ADC) targeting CD33, a protein expressed on the surface of myeloid cells. It is widely recognized ...

I have been in the situation that I’m sure many of us have. I work on genes, which if you name to any right-minded individual, sound like a random string of nonsensical gibberish. So, mayb ...

By John Bannon PhD Early Cytokinesis Early cytokinesis; from anaphase to midbody formation cytokinesis is the physical ...

Quick Facts About Patritumab DeruxtecanWhat is Patritumab Deruxtecan?Patritumab Deruxtecan (HER3-DXd) is an investigational antibody-drug conjugate (ADC) targeting HER3, a receptor impl ...

In the intricate landscape of cellular communication, lies a sophisticated ...

SARS-CoV-2, the causative viral agent of the novel coronavirus disease COVID-19, has sparked a global effort for creating prophylactic and therapeutic interventions. The following ...

Imagine a high-stakes game of hide-and-seek where the seeker is your immune system and the hider is a master of disguise: cancer. For decades, we believed the 'wanted' posters for tumor cells were l ...

Imagine a microscopic sniper, capable of delivering a lethal blow to a single cancer cell while leaving its healthy neighbors virtually untouched. This is the promise of targeted alpha therapy, a re ...

What if our first line of immune defense, the innate immune system, could learn from past encounters to fight future battles more effectively? For decades, we believed this was the exclusive domain o ...

By Rachel Bleach, PhD Student, RCSI By the age of 79 years, 1 in 14 women will develop breast cancer (Global Burden of Disease Cancer 2017). Beatson reporte ...

Incidence rate of Acute Lymphoblastic Leukaemia Acute lymphoblastic leukaemia (ALL) is one of the most common malignant diseases diagnosed in children. It ...

Cell death is an essential aspect of cellular biology that plays a crucial role in development, homeostasis, and disease. In this blog, we try to focus on mechanisms and various typ ...

Esophageal cancer is a type of cancer that affects the esophagus, which is the tube that carries food and liquids from your mouth to your stomach. Esophageal cancer can cause many d ...

Nanosilver is the most commercialised nanoparticle routinely used for its antibacterial purposes in food preservation, cosmetic and health products such as medical devices and wound treatme ...

Pancreatic cancer survival rates Despite recent advances in our understanding of this disease, pancreatic cancer is one of the world’s most lethal maligna ...

In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germ ...

Fluorescence activated cell sorting (FACS) is a cutting-edge technique used to isolate individual cells from a sample and analyse their properties. In this guide, we will discuss the basic ...

Imagine a highly trained soldier, elite and effective, sent to the front lines of a relentless war. Day after day, they fight without rest, their supplies dwindle, and the enemy never stops coming. E ...

Antibiotic resistance is a growing problem in the world today. Antibiotics are becoming less and less effective as bacteria evolve to resist them. This poses a serious threat to hum ...

Fenofibrate, also known as FEN, is a drug that is used to lower cholesterol levels. It works by blocking the absorption of dietary cholesterol in the small intestine and therefore, re ...

Quick Facts About ApamistamabWhat is Apamistamab?Apamistamab is a monoclonal antibody that targets the CD45 antigen on hematopoietic cells.How does Apamistamab work?When labeled with th ...

What is Cortisol? Cortisol is a steroid hormone, classified as a member of the glucocorticoid family of hormones. Cortisol is involved in a plethora of physiological processes in order ...

Ovarian cancer is a set of malignancies that start in the ovaries, as well as adjacent portions of the fallopian tubes and peritoneum. Women have two ovaries, one on each side of the ...

Delving into the world of Lactobacilli, this piece explores their structural intricacies, metabolic functions, and the pivotal role they play in human health. These bacteria, key components in ...

Acute pancreatitis (AP) is a condition in which activated enzymes and inflammatory mediators released from the pancreas cause damage to the pancreas and surrounding tissues. AP is fur ...

By Anusha Senevirante, Post-Doctoral researcher, Imperial College London With non-communicable diseases (or NCDs, which include heart disease, diabetes, c ...

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor epidermal growth factor receptor (EGFR) which triggers ligand-induced ...

Fluorescence Resonance Energy Transfer (FRET) assays represent a pivotal technique in the molecular and cellular biology fields, enabling the examination of protein interactions, nucleic acid str ...

What are Toll Like Receptors? Toll-like receptors (TLRs) are a class of proteins that play a crucial role in the immune system's defense against microbial invaders ...

Nuclear Factor Erythroid 2–Related Factor 2 (NRF2) orchestrates a principal defense mechanism against oxidative stress and plays a pivotal role in inflammation and disease pathogenesis. This arti ...

Hepatocellular carcinoma (HCC) is one of the most frequently occurring cancers and there are 630,000 new cases diagnosed every year worldwide (De Minicis et al. 2013). HCC develops frequently f ...

The Double-Edged Sword: How Neutrophil Traps Can Both Help and Hinder Cancer's Spread In the intricate battlefield of the human body, the immune system’s foot soldiers, neutrophils, have long been r ...

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What is DNA Polymerase Fidelity? The fidelity of a DNA polymerase is the result of accurate replication of a desired template. The fidelity of DNA polymerase ...

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Key Takeaways: Site-directed mutagenesis (SDM) enables precise DNA sequence alterations. Used for investigating protein activity changes and introducing beneficial mutations. GenieClone ki ...

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Assay Genie has developed an extensive suite of assays to measure various forms of cell death. We provide highly sensitive & reprod ...

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1-Step TUNEL Kits Unique 1-Step Non-Toxic Dewaxing Step for Late Stage Apoptosis Detection Explore TUNEL Assays ...

Transcription Factor Assays Detect Transcription Factors via indirect ELISA methods! Detect transcription factors or study transcription fact ...

COVID-19 Nasal Swab Test Nasal/Nasopharyngeal Swabs for Viral Sample Collection The developme ...

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Epigenetic Antibodies Epigenteic Antibodies Organised by Epigenetic Modifications! window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Arr ...

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Knock Out Validated Antibodies Highly specific antibodies for consistent results! Explore KO Antibodies ...

What is IHC? Immunohistochemistry (IHC) is a valuable tool used for the identification of specific antigens within embedded tissue prepara ...

Anti-Tag Antibodies Highly Specific and Non-reactive Anti-Tag Antibodies Explore Anti-Tag Antibodies window.SHOGUN_IMAGE_ELEMENTS = window ...