Anti-SNX27 Antibody (PACO17132)

Antibody Name:	SNX27 Antibody (PACO17132)
Antibody SKU:	PACO17132
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human SNX27

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17132(SNX27 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17132(SNX27 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.

Synonyms:

sorting nexin family member 27

UniProt Protein Function:	SNX27: Involved in endocytic trafficking. In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Vesicle Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: cytoplasm; early endosome; immunological synapse; nucleoplasm; retromer complex Molecular Function:phosphatidylinositol 3-phosphate binding; protein binding Biological Process: endosome transport; establishment of natural killer cell polarity; intracellular protein transport
NCBI Summary:	This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]
UniProt Code:	Q96L92
NCBI GenInfo Identifier:	166214988
NCBI Gene ID:	81609
NCBI Accession:	Q96L92.2
UniProt Secondary Accession:	Q96L92,Q32Q36, Q4AEJ5, Q5VWB0, Q5VWB1, Q5VWB2, Q6IPP6 Q86UB1, Q96D79, Q9H3K8,
UniProt Related Accession:	Q96L92
Molecular Weight:	27,781 Da
NCBI Full Name:	Sorting nexin-27
NCBI Synonym Full Names:	sorting nexin family member 27
NCBI Official Symbol:	SNX27
NCBI Official Synonym Symbols:	MRT1; MY014
NCBI Protein Information:	sorting nexin-27
UniProt Protein Name:	Sorting nexin-27
Protein Family:	Sorting nexin
UniProt Gene Name:	SNX27
UniProt Entry Name:	SNX27_HUMAN

Antibodies

SNX27 Antibody (PACO12382)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)