| UniProt Protein Function: | TM4SF1: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular. Present in high molecular weight complexes in tumor cells.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3q21-q25Cellular Component: integral to plasma membrane |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30408 |
| NCBI GenInfo Identifier: | 267068 |
| NCBI Gene ID: | 4071 |
| NCBI Accession: | P30408.1 |
| UniProt Secondary Accession: | P30408,Q6IB51 |
| UniProt Related Accession: | P30408 |
| Molecular Weight: | 21,632 Da |
| NCBI Full Name: | Transmembrane 4 L6 family member 1 |
| NCBI Synonym Full Names: | transmembrane 4 L six family member 1 |
| NCBI Official Symbol: | TM4SF1Â Â |
| NCBI Official Synonym Symbols: | L6; H-L6; M3S1; TAAL6Â Â |
| NCBI Protein Information: | transmembrane 4 L6 family member 1 |
| UniProt Protein Name: | Transmembrane 4 L6 family member 1 |
| UniProt Synonym Protein Names: | Membrane component chromosome 3 surface marker 1; Tumor-associated antigen L6 |
| Protein Family: | Transmembrane 4 L6 family |
| UniProt Gene Name: | TM4SF1Â Â |
| UniProt Entry Name: | T4S1_HUMAN |
