Anti-ADORA3 Antibody (PACO23513)

Antibody Name:	ADORA3 Antibody (PACO23513)
Antibody SKU:	PACO23513
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human Adenosine receptor A3

Form:	Liquid
Storage Buffer:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purification Method:	Antigen Affinity Purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Gel: 10%SDS-PAGE Lysates (from left to right): Mouse testis tissue Amount of lysate: 20ug per lane Primary antibody: 1/100 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute.
	Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/20.

Background:

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms:

A3AR; AD026

UniProt Protein Function:	ADORA3: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p13.2Cellular Component: mast cell granule; integral to plasma membrane; plasma membraneMolecular Function: adenosine receptor activity, G-protein coupledBiological Process: positive regulation of phosphoinositide 3-kinase cascade; histamine secretion by mast cell; positive regulation of leukocyte migration; adenylate cyclase activation; response to wounding; positive regulation of mast cell degranulation; positive regulation of calcium-mediated signaling; signal transduction; inflammatory response; adenosine receptor signaling pathway; regulation of heart contraction; positive regulation of inflammatory response
UniProt Protein Details:
NCBI Summary:	This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
UniProt Code:	P33765
NCBI GenInfo Identifier:	1351831
NCBI Gene ID:	140
NCBI Accession:	P33765.2
UniProt Secondary Accession:	P33765,Q6UWU0, Q9BYZ1, A2A3P4
UniProt Related Accession:	P33765
Molecular Weight:	Calculated MW: 36kDaObserved MW: 37kDa
NCBI Full Name:	Adenosine receptor A3
NCBI Synonym Full Names:	adenosine A3 receptor
NCBI Official Symbol:	ADORA3
NCBI Official Synonym Symbols:	A3AR
NCBI Protein Information:	adenosine receptor A3
UniProt Protein Name:	Adenosine receptor A3
UniProt Synonym Protein Names:
Protein Family:	Adenosine receptor
UniProt Gene Name:	ADORA3
UniProt Entry Name:	AA3R_HUMAN

Antibodies

ADORA3 Antibody (PACO03505)

ADORA3 Antibody (PACO06237)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)