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Anti-BCAR3 Antibody (CAB18395)

SKU:
CAB18395
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€129 - €359
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Description

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Antibody Name:Anti-BCAR3 Antibody
Antibody SKU:CAB18395
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human BCAR3.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human BCAR3.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8412
Uniprot:O75815
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:NSP2, SH2D3B, BCAR3
Background:
UniProt Protein Function:BCAR3: a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described.
UniProt Protein Details:

Protein type:GEFs; Adaptor/scaffold; Motility/polarity/chemotaxis; GEFs, Ras

Chromosomal Location of Human Ortholog: 1p22.1

Cellular Component: intracellular

Molecular Function:guanyl-nucleotide exchange factor activity; protein binding

Biological Process: lens morphogenesis in camera-type eye; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; response to drug; signal transduction; small GTPase mediated signal transduction

NCBI Summary:Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
UniProt Code:O75815
NCBI GenInfo Identifier:74739634
NCBI Gene ID:8412
NCBI Accession:O75815.1
UniProt Secondary Accession:O75815,Q5TEW3, Q6UW40, Q9BR50, D3DT43,
UniProt Related Accession:O75815
Molecular Weight:82,357 Da
NCBI Full Name:Breast cancer anti-estrogen resistance protein 3
NCBI Synonym Full Names:breast cancer anti-estrogen resistance 3
NCBI Official Symbol:BCAR3  
NCBI Official Synonym Symbols:NSP2; SH2D3B  
NCBI Protein Information:breast cancer anti-estrogen resistance protein 3
UniProt Protein Name:Breast cancer anti-estrogen resistance protein 3
UniProt Synonym Protein Names:Novel SH2-containing protein 2; SH2 domain-containing protein 3B
Protein Family:Breast cancer anti-estrogen resistance protein
UniProt Gene Name:BCAR3  
UniProt Entry Name:BCAR3_HUMAN

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