BIN2 Antibody (PACO56736)
- SKU:
- PACO56736
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | BIN2 Antibody (PACO56736) |
| Antibody SKU: | PACO56736 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Bridging integrator 2 protein (290-496AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of HepG2 cells with PACO56736 at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | IHC image of PACO56736 diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO56736 diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. |
| Synonyms: | Bridging integrator 2 (Breast cancer-associated protein 1), BIN2, BRAP1 |
| UniProt Protein Function: | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9UBW5 |
| NCBI GenInfo Identifier: | 143811367 |
| NCBI Gene ID: | 51411 |
| NCBI Accession: | Q9UBW5.3 |
| UniProt Secondary Accession: | Q9UBW5,Q86VV0, Q9NWK4, Q9UKN4 |
| UniProt Related Accession: | Q9UBW5 |
| Molecular Weight: | 58,030 Da |
| NCBI Full Name: | Bridging integrator 2 |
| NCBI Synonym Full Names: | bridging integrator 2 |
| NCBI Official Symbol: | BIN2Â Â |
| NCBI Official Synonym Symbols: | BRAP-1Â Â |
| NCBI Protein Information: | bridging integrator 2 |
| UniProt Protein Name: | Bridging integrator 2 |
| UniProt Synonym Protein Names: | Breast cancer-associated protein 1 |
| Protein Family: | Bridging integrator |
| UniProt Gene Name: | BIN2Â Â |
| UniProt Entry Name: |
| Antibodies |
| BIN2 Antibody (PACO08014) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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