CLEC9A Antibody (PACO46642)
- SKU:
- PACO46642
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | CLEC9A Antibody (PACO46642) |
| Antibody SKU: | PACO46642 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human C-type lectin domain family 9 member A protein (103-214AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CLEC9A antibody IgG at 8µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 27 kDa. Observed band size: 27 kDa.. |
 | Immunofluorescent analysis of MCF-7 cells using PACO46642 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. |
| Synonyms: | C-type lectin domain family 9 member A, CLEC9A |
| UniProt Protein Function: | CLEC9A: Functions as an endocytic receptor on a small subset of myeloid cells and induces intracellular signaling via spleen tyrosine kinase (Syk). Acts as a receptor for necrotic cells and can mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 12p13.2Cellular Component: cell surfaceBiological Process: positive regulation of cytokine secretion; receptor-mediated endocytosis |
| UniProt Protein Details: | |
| NCBI Summary: | CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008] |
| UniProt Code: | Q6UXN8 |
| NCBI GenInfo Identifier: | 73917794 |
| NCBI Gene ID: | 283420 |
| NCBI Accession: | Q6UXN8.1 |
| UniProt Secondary Accession: | Q6UXN8,B0ZBM2 |
| UniProt Related Accession: | Q6UXN8 |
| Molecular Weight: | 27,324 Da |
| NCBI Full Name: | C-type lectin domain family 9 member A |
| NCBI Synonym Full Names: | C-type lectin domain family 9 member A |
| NCBI Official Symbol: | CLEC9AÂ Â |
| NCBI Official Synonym Symbols: | CD370; DNGR1; DNGR-1; UNQ9341Â Â |
| NCBI Protein Information: | C-type lectin domain family 9 member A |
| UniProt Protein Name: | C-type lectin domain family 9 member A |
| UniProt Synonym Protein Names: | |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC9AÂ Â |
| UniProt Entry Name: | CLC9A_HUMAN |
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