| UniProt Protein Function: | EPS8L2: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Belongs to the EPS8 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Actin-binding; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; plasma membrane; protein complex; vesicleMolecular Function: actin binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activityBiological Process: regulation of Rho protein signal transduction; Rho protein signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9H6S3 |
| NCBI GenInfo Identifier: | 108864726 |
| NCBI Gene ID: | 64787 |
| NCBI Accession: | Q9H6S3.2 |
| UniProt Secondary Accession: | Q9H6S3,Q53GM8, Q8WYW7, Q96K06, Q9H6K9, B3KSX1, B7ZKL3 |
| UniProt Related Accession: | Q9H6S3 |
| Molecular Weight: | 82,323 Da |
| NCBI Full Name: | Epidermal growth factor receptor kinase substrate 8-like protein 2 |
| NCBI Synonym Full Names: | EPS8 like 2 |
| NCBI Official Symbol: | EPS8L2Â Â |
| NCBI Official Synonym Symbols: | EPS8R2Â Â |
| NCBI Protein Information: | epidermal growth factor receptor kinase substrate 8-like protein 2 |
| UniProt Protein Name: | Epidermal growth factor receptor kinase substrate 8-like protein 2 |
| UniProt Synonym Protein Names: | Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-related protein 2 |
| Protein Family: | Epidermal growth factor receptor kinase substrate 8-like protein |
| UniProt Gene Name: | EPS8L2Â Â |
| UniProt Entry Name: | ES8L2_HUMAN |
