Human UBD Recombinant Protein (RPPB5062)
- SKU:
- RPPB5062
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O15205
Description
| Product Name: | Human UBD Recombinant Protein |
| Product Code: | RPPB5062 |
| Size: | 5µg |
| Species: | Human |
| Target: | UBD |
| Synonyms: | Ubiquitin D, Diubiquitin, Ubiquitin-like protein FAT10, UBD, FAT10, UBD-3, GABBR1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UBD protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAPNASC LCVHVRSEEW DLMTFDANPY DSVKKIKEHV RSKTKVPVQD QVLLLGSKIL KPRRSLSSYG IDKEKTIHLT LKVVKPSDEE LPLFLVESGD EAKRHLLQVR RSSSVAQVKA MIETKTGIIP ETQIVTCNGK RLEDGKMMAD YGIRKGNLLF LACYCIGG |
Ubiquitin D (UBD) is an ubiquitin-like modifier (UBL) of the ubiquitin protein family. UBD is an ubiquitin-like protein which can form covalent conjugates, thus targeting proteins for degradation by the 26S proteasome. It is assumed that, UBD has roles in regulation of cell cycle, innate immunity, and apoptosis. UBD is a TNF-a inducible ubiquitin-like protein with a presumed role in the immune response.
UBD Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-165 a.a.) and having a molecular mass of 20.9kDa.UBD is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FAT10: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN). |
| UniProt Protein Details: | Protein type:Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function:protein binding Biological Process: myeloid dendritic cell differentiation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein modification by small protein conjugation; protein ubiquitination; proteolysis; response to organic nitrogen; ubiquitin-dependent protein catabolic process |
| UniProt Code: | O15205 |
| NCBI GenInfo Identifier: | 269849476 |
| NCBI Gene ID: | 10537 |
| NCBI Accession: | O15205.2 |
| UniProt Secondary Accession: | O15205,Q5STL2, Q5SUK2, Q96EC7, B0UZT6, |
| UniProt Related Accession: | O15205 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin D |
| NCBI Synonym Full Names: | ubiquitin D |
| NCBI Official Symbol: | UBD�� |
| NCBI Official Synonym Symbols: | FAT10; UBD-3; GABBR1�� |
| NCBI Protein Information: | ubiquitin D |
| UniProt Protein Name: | Ubiquitin D |
| UniProt Synonym Protein Names: | Diubiquitin; Ubiquitin-like protein FAT10 |
| Protein Family: | Ubiquitin |
| UniProt Gene Name: | UBD�� |
| UniProt Entry Name: | UBD_HUMAN |
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