Human HDGF Recombinant Protein (RPPB0367)
- SKU:
- RPPB0367
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P51858
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human HDGF Recombinant Protein |
| Product Code: | RPPB0367 |
| Size: | 20µg |
| Species: | Human |
| Target: | HDGF |
| Synonyms: | High-mobility group protein 1-like 2, HMG1L2, HMG-1L2, Hepatoma-derived growth factor, HDGF, FLJ96580, DKFZp686J1764. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The HDGF protein solution (1mg/ml) is formulated in 20mM Tris-HCl pH-7.5, 1mM DTT, 10% glycerol and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY |
HDGF is a member of the hepatoma-derived growth factor family. HDGF plays a role as a secreted mitogen from the human hepatoma cell line Huh-7. HDGF is a nuclear targeted vascular smooth muscle cell mitogen as well as a heparin-binding protein that is greatly expressed in tumor cells where it stimulates proliferation. HDGF takes part in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. HDGF plays a role in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation. HDGF is linked with tumorigenesis and the growth of cancer. HDGF is a self-regulating factor connected with the prognosis of liver cancer, non-small cell lung cancer and pancreatic cancer. HDGF has proliferative, angiogenic, and neurotrophic activity. HDGF is a distinctive nuclear targeting growth factor that is vastly expressed in HCC cells and is a prognostic factor for HCC.
The HDGF Human recombinant protein is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 11.5kDa and containing 100 amino acids.The HDGF is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. |
| NCBI Summary: | This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P51858 |
| NCBI GenInfo Identifier: | 1708157 |
| NCBI Gene ID: | 3068 |
| NCBI Accession: | P51858.1 |
| UniProt Secondary Accession: | P51858,Q5SZ07, Q5SZ08, Q5SZ09, B3KU21, D3DVC9, |
| UniProt Related Accession: | P51858 |
| Molecular Weight: | 28,264 Da |
| NCBI Full Name: | Hepatoma-derived growth factor |
| NCBI Synonym Full Names: | hepatoma-derived growth factor |
| NCBI Official Symbol: | HDGF�� |
| NCBI Official Synonym Symbols: | HMG1L2�� |
| NCBI Protein Information: | hepatoma-derived growth factor |
| UniProt Protein Name: | Hepatoma-derived growth factor |
| UniProt Synonym Protein Names: | High mobility group protein 1-like 2; HMG-1L2 |
| Protein Family: | Hepatoma-derived growth factor |
| UniProt Gene Name: | HDGF�� |
| UniProt Entry Name: | HDGF_HUMAN |
