Human Tyr-3/Trp-5 Monooxygenase Activation Protein, Gamma His Tag Recombinant Protein (CPRT2685)

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YWHAgHuman, His Recombinant Protein

Name:YWHAgHuman, His
Synonyms:14-3-3 protein gamma, Protein kinase C inhibitor protein 1, KCIP-1, YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide.
Introduction:The 14–3–3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient–sensingpathways. 14–3–3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms that have been identified in mammals. The 14–3–3gamma, a subtype of the 14–3–3 family of proteins, was thought to be brain and neuron–specific. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.
Description:YWHAgHuman Recombinant produced in E.Coli is a single, non–glycosylated, polypeptide chain containing 246 amino acids (2–247) and having a molecular mass of 36 kDa. YWHAgis fused to His Tagand purified by proprietary chromatographic techniques.
Source:Escherichia Coli.
Pack size:10µg
Physical Appearance:Sterile filtered colorless solution.
Formulation:YWHAgsolution containing 1x PBS and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2–4 weeks. Store, frozen at –20°C for longer periods of time. Avoid multiple freeze–thaw cycles.
Purity:Greater than 95.0% as determined by SDS–PAGE.
Amino Acid Sequence:N/A
Biological Activity:N/A
Usage:Assay Genie’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

YWHAgHuman, His Recombinant Protein - Protein Information

UniProt Protein Function:14-3-3 gamma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with SAMSN1. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Highly expressed in brain, skeletal muscle, and heart. Belongs to the 14-3-3 family.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytoplasmic vesicle membrane; cytosol; focal adhesion; membrane

Molecular Function:insulin-like growth factor receptor binding; protein binding; protein kinase C binding

Biological Process: G2/M transition of mitotic cell cycle; regulation of neuron differentiation; regulation of synaptic plasticity

NCBI Summary:This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
UniProt Code:P61981
NCBI GenInfo Identifier:48428721
NCBI Gene ID:7532
NCBI Accession:P61981.2
UniProt Secondary Accession:P61981,O70457, P35214, Q6FH52, Q9UDP2, Q9UN99,
UniProt Related Accession:P61981
Molecular Weight:28,303 Da
NCBI Full Name:14-3-3 protein gamma
NCBI Synonym Full Names:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
NCBI Official Symbol:YWHAG  
NCBI Official Synonym Symbols:PPP1R170; 14-3-3GAMMA  
NCBI Protein Information:14-3-3 protein gamma
UniProt Protein Name:14-3-3 protein gamma
UniProt Synonym Protein Names:Protein kinase C inhibitor protein 1; KCIP-1
Protein Family:14-3-3 protein
UniProt Gene Name:YWHAG  
UniProt Entry Name:1433G_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host Species:
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