| UniProt Protein Function: | IL18RAP: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Belongs to the interleukin-1 receptor family.Protein type: Cell surface; Membrane protein, integralChromosomal Location of Human Ortholog: 2q12Cellular Component: integral to membraneMolecular Function: receptor activityBiological Process: cell surface receptor linked signal transduction; immune response; inflammatory response |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] |
| UniProt Code: | O95256 |
| NCBI GenInfo Identifier: | 74762124 |
| NCBI Gene ID: | 8807 |
| NCBI Accession: | O95256.1 |
| UniProt Secondary Accession: | O95256,Q3KPE7, Q3KPE8, Q53TT4, Q53TU5, B2RPJ3 |
| UniProt Related Accession: | O95256 |
| Molecular Weight: | 599 |
| NCBI Full Name: | Interleukin-18 receptor accessory protein |
| NCBI Synonym Full Names: | interleukin 18 receptor accessory protein |
| NCBI Official Symbol: | IL18RAPÂ Â |
| NCBI Official Synonym Symbols: | ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta  |
| NCBI Protein Information: | interleukin-18 receptor accessory protein; IL-18 receptor beta; interleukin-1 receptor 7; interleukin-18 receptor beta; IL-18 receptor accessory protein; cluster of differentiation w218b; CD218 antigen-like family member B |
| UniProt Protein Name: | Interleukin-18 receptor accessory protein |
| UniProt Synonym Protein Names: | Accessory protein-like; AcPL; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like; IL-1RAcPL; Interleukin-1 receptor 7; IL-1R-7; IL-1R7; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta; IL-18R-beta; IL-18Rbeta; CD_antigen: CD218b |
| Protein Family: | |
| UniProt Gene Name: | IL18RAPÂ Â |
| UniProt Entry Name: | I18RA_HUMAN |
