[KD Validated] JNK1 Monoclonal Antibody
- SKU:
- CAB21888
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | [KD Validated] JNK1 Monoclonal Antibody |
Product Code: | CAB21888 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC2908 |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:500-1:1000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Positive Samples: | 293T, C6, Neuro-2a, Mouse heart, Rat testis, Rat brain |
Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human JNK1 (P45983). |
Sequence: | KKLQP TVRTY VENRP KYAGY SFEKL FPDVL FPADS EHNKL KASQA RDLLS KMLVI DASKR ISVDE ALQHP YINVW YDPSE AEAPP PKIPD KQLDE REHTI E |
Synonyms: | JNK |
Calculated MW: | 48kDa |
Observed MW: | 46kDa/54kDa |