Anti-KMO Antibody (PACO43748)

Antibody Name:	KMO Antibody (PACO43748)
Antibody SKU:	PACO43748
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Recombinant Human Kynurenine 3-monooxygenase protein (1-260AA)

Form:	Liquid
Storage Buffer:	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:	Antigen Affinity Purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot. All lanes: KMO antibody at 10µg/ml + Mouse heart tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 56, 55, 52 kDa. Observed band size: 56 kDa.
	Immunohistochemistry of paraffin-embedded human breast cancer using PACO43748 at dilution of 1:100.

Background:

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid, may also affect NMDA receptor signaling in pancreatic β cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Synonyms:

Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase), KMO

UniProt Protein Function:	KMO: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; Membrane protein, integral; Amino Acid Metabolism - tryptophan; Mitochondrial; EC 1.14.13.9; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q42-q44Cellular Component: cytosol; mitochondrial outer membraneMolecular Function: FAD binding; kynurenine 3-monooxygenase activity; NAD(P)H oxidase activityBiological Process: NAD metabolic process; response to salt stress; tryptophan catabolic process
UniProt Protein Details:
NCBI Summary:	This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
UniProt Code:	O15229
NCBI GenInfo Identifier:	126302562
NCBI Gene ID:	8564
NCBI Accession:	O15229.2
UniProt Secondary Accession:	O15229,Q5SY07, Q5SY08, Q5SY09, A2A2U8, A2A2U9, A2A2V0
UniProt Related Accession:	O15229
Molecular Weight:	51,682 Da
NCBI Full Name:	Kynurenine 3-monooxygenase
NCBI Synonym Full Names:	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
NCBI Official Symbol:	KMO
NCBI Official Synonym Symbols:	dJ317G22.1
NCBI Protein Information:	kynurenine 3-monooxygenase
UniProt Protein Name:	Kynurenine 3-monooxygenase
UniProt Synonym Protein Names:	Kynurenine 3-hydroxylase
Protein Family:
UniProt Gene Name:	KMO
UniProt Entry Name:	KMO_HUMAN

Antibodies	ELISA Kits
KMO Antibody (PACO10149)	Human Kynurenine 3-monooxygenase (KMO) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)