| UniProt Protein Function: | MRPL33: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 2p21Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosome |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75394 |
| NCBI GenInfo Identifier: | 74735511 |
| NCBI Gene ID: | 9553 |
| NCBI Accession: | O75394.1 |
| UniProt Secondary Accession: | O75394,Q53RZ6, Q5FVE3, Q96Q50 |
| UniProt Related Accession: | O75394 |
| Molecular Weight: | 5,965 Da |
| NCBI Full Name: | 39S ribosomal protein L33, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L33 |
| NCBI Official Symbol: | MRPL33Â Â |
| NCBI Official Synonym Symbols: | L33mt; C2orf1; RPL33L; MRP-L33Â Â |
| NCBI Protein Information: | 39S ribosomal protein L33, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L33, mitochondrial |
| UniProt Synonym Protein Names: | |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL33Â Â |
| UniProt Entry Name: | RM33_HUMAN |
