Notch1 Polyclonal Antibody (CAB16674)
- SKU:
- CAB16674
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | Notch1 Polyclonal Antibody |
SKU: | CAB16674 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2381-2480 of human Notch1 (NP_060087.3). |
Sequence: | QTQQ VQPQ NLQM QQQN LQPA NIQQ QQSL QPPP PPPQ PHLG VSSA ASGH LGRS FLSG EPSQ ADVQ PLGP SSLA VHTI LPQE SPAL PTSL PSSL VPPV TAAQ |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200 |
Synonyms: | hN1; AOS5; TAN1; AOVD1; Notch1 |
Positive Sample: | HeLa,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Nucleus, Single-pass type I membrane protein. |
Calculated MW: | 273kDa |
Observed MW: | 110kDa/120kDa |
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Purification Method: | Affinity purification |
Gene ID: | 4851 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |