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Anti-P2RX3 Antibody (CAB10232)

SKU:
CAB10232
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
$167 - $503
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Description

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Antibody Name:Anti-P2RX3 Antibody
Antibody SKU:CAB10232
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 44-317 of human P2RX3 (NP_002550.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Rat
Positive Samples:Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 44-317 of human P2RX3 (NP_002550.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LHEK AYQV RDTA IESS VVTK VKGS GLYA NRVM DVSD YVTP PQGT SVFV IITK MIVT ENQM QGFC PESE EKYR CVSD SQCG PERL PGGG ILTG RCVN YSSV LRTC EIQG WCPT EVDT VETP IMME AENF TIFI KNSI RFPL FNFE KGNL LPNL TARD MKTC RFHP DKDP FCPI LRVG DVVK FAGQ DFAK LART GGVL GIKI GWVC DLDK AWDQ CIPK YSFT RLDS VSEK SSVS PGYN FRFA KYYK MENG SEYR TLLK AFGI RFDV LVYG NAGK FN
Gene ID:5024
Uniprot:P56373
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:44kDa
Observed MW:44kDa
Synonyms:P2RX3, P2X3
Background:The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
UniProt Protein Function:P2X3: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: Golgi apparatus; cell soma; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex; lipid raft

Molecular Function:ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity

Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; generation of action potential; regulation of synaptic plasticity; positive regulation of calcium-mediated signaling; signal transduction; response to ATP; response to carbohydrate stimulus; behavioral response to pain; transport; response to heat; response to mechanical stimulus; response to hypoxia; neuromuscular synaptic transmission; response to cold; protein homooligomerization

NCBI Summary:This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]
UniProt Code:P56373
NCBI GenInfo Identifier:259016295
NCBI Gene ID:5024
NCBI Accession:
UniProt Related Accession:P56373
Molecular Weight:
NCBI Full Name:P2X purinoceptor 3
NCBI Synonym Full Names:purinergic receptor P2X 3
NCBI Official Symbol:P2RX3  
NCBI Official Synonym Symbols:P2X3  
NCBI Protein Information:P2X purinoceptor 3
UniProt Protein Name:P2X purinoceptor 3
UniProt Synonym Protein Names:ATP receptor; Purinergic receptor
UniProt Gene Name:P2RX3  
UniProt Entry Name:P2RX3_HUMAN
Anti-P2RX3 Antibody (CAB10232)Western blot analysis of extracts of rat testis, using P2RX3 antibody (CAB10232) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.

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