Phospho-ErbB2-Y1221/Y1222 Monoclonal Antibody
- SKU:
- CABP1424
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Phospho-ErbB2-Y1221/Y1222 Monoclonal Antibody |
| Product Code: | CABP1424 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC3121 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A-431 |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus, Nucleus, Single-pass type I membrane protein, Perinuclear region |
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding Y1221&Y1222 of Human ErbB2. |
| Sequence: | Email for sequence |
| Synonyms: | NEU, NGL, HER2, TKR1, CD340, HER-2, VSCN2, MLN 19, MLN-19, c-ERB2, c-ERB-2, HER-2/neu, p185(erbB2) |
| Calculated MW: | 138kDa |
| Observed MW: | 185kDa |
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