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Phospho-IRE1-S724 Monoclonal Antibody

SKU:
CABP1442
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
IHC
€139 - €609
Frequently bought together:

Description

Product Name:Phospho-IRE1-S724 Monoclonal Antibody
Product Code:CABP1442
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC62282
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence, Immunohistochemistry
Recommended Dilution:WB 1:1000-1:5000, IF/ICC 1:50-1:200, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa+CA
Cellular Location:Endoplasmic reticulum membrane, Single-pass type I membrane protein

This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.

Immunogen:A synthetic phosphorylated peptide around S724 of human IRE1(NP_001424.3).
Sequence:RHSFS
Synonyms:IRE1, IRE1P, IRE1a, hIRE1p
Calculated MW:110kDa
Observed MW:130kDa

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