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Phospho-MKK3-S189+MKK6-S207 Monoclonal Antibody (CABP1449)

SKU:
CABP1449
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
€139 - €609
Frequently bought together:

Description

Product Name:Phospho-MKK3-S189+MKK6-S207 Monoclonal Antibody
Product Code:CABP1449
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC62482
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, ELISA
Key Applications:Western blotting, Immunohistochemistry
Recommended Dilution:WB 1:500-1:1000, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa+UV, NIH/3T3+UV
Cellular Location:cytosol, nucleoplasm

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Immunogen:A synthetic phosphorylated peptide around S207 of human MKK3/MKK6(P46734/P52564).
Sequence:VDSVA
Synonyms:MAP2K3/MAP2K6
Calculated MW:36kDa/39kDa/31kDa/37kDa
Observed MW:38kDa/40kDa

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