Human Cathepsin L/CTSL Recombinant Protein (RPES4674)

SKU:
RPES4674
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
€361

Description

ELISA Kit Technical Manual

Recombinant Human Cathepsin L/CTSL Protein (His Tag)

Background:Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tumor invasion and metastasis, bone resorption, and turnover of intracellular and secreted proteins involved in growth regulation. Unlike the precursor forms of other papain family members, the 43 kDa pro-cathepsin L itself is secreted from various cells. Pro-cathepsin L is the major excreted protein of malignantly transformed mouse fibroblasts and is also one of the major acidic cysteine proteases in mammalian cells.
Name:Recombinant Human Cathepsin L/CTSL Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES4674
Synonyms:Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL
Species:Human
Expression host:Human Cells
Sequence:Thr18-Val333
Accession:P07711
Mol Mass:36.9 kDa
AP Mol Mass:34 kDa
Tag:C-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.5.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:Important for the overall degradation of proteins in lysosomes.
NCBI Summary:The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:P07711
NCBI GenInfo Identifier:115741
NCBI Gene ID:1514
NCBI Accession:P07711.2
UniProt Secondary Accession:P07711,Q6IAV1, Q96QJ0,
UniProt Related Accession:P07711
Molecular Weight:38kDa
NCBI Full Name:Cathepsin L1
NCBI Synonym Full Names:cathepsin L
NCBI Official Symbol:CTSL
NCBI Official Synonym Symbols:MEP; CATL; CTSL1
NCBI Protein Information:cathepsin L1
UniProt Protein Name:Cathepsin L1
UniProt Synonym Protein Names:Cathepsin L; Major excreted protein; MEP
UniProt Gene Name:CTSL
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