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Human CD80/B7 Recombinant Protein (RPES3616)

SKU:
RPES3616
Product Type:
Recombinant Protein
Species:
Human
€150
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Description

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Human CD80/B7 Recombinant Protein

Cluster of Differentiation 80; also called B7-1; is a member of cell surface immunoglobulin superfamily which plays key; yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells; macrophages and dendritic cells.

Product Name:Human CD80/B7 Recombinant Protein (RPES3616)
Product Code:RPES3616
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:CD80, Activation B7-1 antigen, B7, BB1, CD28LG1, CD28LGB7-1 antigen, T-lymphocyte activation antigen CD80,B7-1,B7.1,CD28LG,LAB7
Accession:NP_005182.1
Sequence:Val35-Asn242
Fusion tag:C-6His
Activity:Immobilized Human CD28-Fc(Cat: PKSH032211) at 10µg/ml(100 ?l/well) can bind Human B7-1 -His. The ED50 of Human B7-1 -His is 14.3 ug/mL
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Activation B7-1 antigen is produced by our Mammalian expression system and the target gene encoding Val35-Asn242 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:24.7 kDa
AP Mol Mass:38-60 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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