Anti-RRAD Antibody (PACO23803)

Antibody Name:	RRAD Antibody (PACO23803)
Antibody SKU:	PACO23803
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from internal of human RAD.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot analysis of extracts from HeLa cells, HepG2 cells and MCF-7 cells, using RAD antibody.
	Immunofluorescence analysis of A549 cells, using RAD antibody.
	Immunohistochemistry analysis of paraffin-embedded human heart tissue using RAD antibody.

Background:	May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane By similarity. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
Synonyms:	GTP-binding protein RAD; RAD; RAD1; RAS associated with diabetes;

UniProt Protein Function:	RRAD: a small G protein of the RGK family. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Interacts with calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Protein type: G protein, monomeric, RGK; G protein; G protein, monomericChromosomal Location of Human Ortholog: 16q22Cellular Component: plasma membraneMolecular Function: calmodulin binding; GTPase activity; protein binding; GTP bindingBiological Process: metabolic process; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
UniProt Code:	P55042
NCBI GenInfo Identifier:	192807327
NCBI Gene ID:	6236
NCBI Accession:	NP_001122322.1
UniProt Secondary Accession:	P55042,Q96F39
UniProt Related Accession:	P55042
Molecular Weight:	33,245 Da
NCBI Full Name:	GTP-binding protein RAD
NCBI Synonym Full Names:	Ras-related associated with diabetes
NCBI Official Symbol:	RRAD
NCBI Official Synonym Symbols:	RAD; RAD1; REM3
NCBI Protein Information:	GTP-binding protein RAD; ras associated with diabetes; RAS (RAD and GEM) like GTP binding 3
UniProt Protein Name:	GTP-binding protein RAD
UniProt Synonym Protein Names:	RAD1; Ras associated with diabetes
Protein Family:	GTP-binding protein
UniProt Gene Name:	RRAD
UniProt Entry Name:	RAD_HUMAN

Antibodies

RRAD Antibody (PACO01393)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)