Low Endotoxin Purified Anti-Human CD28 Antibody [CD28.2] (AGEL2019)
- SKU:
- AGEL2019
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Applications:
- FC
Frequently bought together:
Description
Product Title: | Low Endotoxin Purified Anti-Human CD28 Antibody [CD28.2] |
SKU: | AGEL2019 |
Size: | 50µg, 500µg, 1mg |
Clone No: | CD28.2 |
Synonyms: | PAS2;MNS;HGpMiX;GYPA;GPSAT; |
Host Species: | Mouse |
Reactivity: | Human |
Application: | FCM;Activ |
Isotype: | Mouse IgG1, κ |
Isotype Control: | AF/LE Purified Mouse IgG1, κ Isotype Control[MOPC-21] |
Form: | Liquid |
Conjugation: | None (AF/LE) |
Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Swissprot: | P10747 |
Gene ID: | 940 |
Storage Buffer: | 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
Stability & Storage: | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Background: | CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. |