Anti-Phospho-CENPA-S7 Antibody (CABP1183)

Product Name:	Phospho-CENPA-S7 Rabbit pAb
Product Code:	CABP1183
Size:	20uL, 50uL, 100uL
Synonyms:	CENP-A, CenH3
Applications:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthetic phosphorylated peptide around S7 of human CENPA (NP_001035891.1).

Applications:	WB
Recommended Dilutions:	WB 1:500 - 1:2000
Reactivity:	Human

Immunogen:	A synthetic phosphorylated peptide around S7 of human CENPA (NP_001035891.1).
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	1058
Uniprot:	P49450
Observed MW:	Refer to figures

UniProt Protein Function:	CENPA: a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: chromosome, pericentric region; condensed nuclear chromosome, pericentric region; cytosol; nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding Biological Process: DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; kinetochore assembly; sister chromatid cohesion
NCBI Summary:	Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
UniProt Code:	P49450
NCBI GenInfo Identifier:	1345726
NCBI Gene ID:	1058
NCBI Accession:	P49450.1
UniProt Secondary Accession:	P49450,Q53T74, Q9BVW2, D6W544,
UniProt Related Accession:	P49450
Molecular Weight:	13,001 Da
NCBI Full Name:	Histone H3-like centromeric protein A
NCBI Synonym Full Names:	centromere protein A
NCBI Official Symbol:	CENPA
NCBI Official Synonym Symbols:	CenH3; CENP-A
NCBI Protein Information:	histone H3-like centromeric protein A
UniProt Protein Name:	Histone H3-like centromeric protein A
UniProt Synonym Protein Names:	Centromere autoantigen A; Centromere protein A; CENP-A
Protein Family:	Histone H3-like centromeric protein
UniProt Gene Name:	CENPA
UniProt Entry Name:	CENPA_HUMAN