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Anti-HDAC7 Antibody (CAB16532)

SKU:
CAB16532
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-HDAC7 Antibody CAB16532
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-HDAC7 Antibody CAB16532
$167 - $503
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Description

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Antibody Name:Anti-HDAC7 Antibody
Antibody SKU:CAB16532
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human HDAC7 (NP_056216.2).
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human HDAC7 (NP_056216.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPPS ATAP PPPG PMQP RLEQ LKTH VQVI KRSA KPSE KPRL RQIP SAED LETD GGGP GQVV DDGL EHRE LGHG QPEA RGPA PLQQ HPQV LLWE QQRL AGRL P
Gene ID:51564
Uniprot:Q8WUI4
Cellular Location:Cytoplasm, Nucleus
Calculated MW:46-66kDa, 99-108kDa
Observed MW:
Synonyms:HDAC7, HD7, HD7A, HDAC7A
Background:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
NCBI Summary:Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WUI4
NCBI GenInfo Identifier:30913097
NCBI Gene ID:51564
NCBI Accession:Q8WUI4.2
UniProt Secondary Accession:Q8WUI4,Q6P1W9, Q6W9G7, Q7Z4K2, Q7Z5I1, Q96K01, Q9BR73 Q9H7L0, Q9NW41, B3KY08, B4DWI0, B4E0Q5,
UniProt Related Accession:Q8WUI4
Molecular Weight:66,187 Da
NCBI Full Name:Histone deacetylase 7
NCBI Synonym Full Names:histone deacetylase 7
NCBI Official Symbol:HDAC7  
NCBI Official Synonym Symbols:HD7; HD7A; HDAC7A  
NCBI Protein Information:histone deacetylase 7
UniProt Protein Name:Histone deacetylase 7
UniProt Synonym Protein Names:Histone deacetylase 7A; HD7a
Protein Family:Histone deacetylase
UniProt Gene Name:HDAC7  
UniProt Entry Name:HDAC7_HUMAN
Anti-HDAC7 Antibody (CAB16532)Immunohistochemistry of paraffin-embedded rat pancreas using HDAC7 antibody (CAB16532) at dilution of 1:100 (40x lens).
Anti-HDAC7 Antibody (CAB16532)Immunohistochemistry of paraffin-embedded human placenta using HDAC7 antibody (CAB16532) at dilution of 1:100 (40x lens).

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