Human CD74 Recombinant Protein (CPRT3051)

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Recombinant Protein DatasheetAntibody MSDS

CD74 Human Recombinant Protein

Name:CD74 Human
Synonyms:DHLAG, HLADG, Ia-GAMMA, li, HLA-DR antigens-associated invariant chain, p33, Ia antigen-associated invariant chain, HLA class II histocompatibility antigen gamma chain, CD74, Gamma Chain Of Class II Antigens, MHC HLA-DR Gamma Chain.
Introduction:CD74 (HLA class II histocompatibility antigen gamma chain isoform b), is a transmembrane protein (on antigen presentingcells) which is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. CD74 upregulated in several cancers and is also expressed by non immune cells duringinflammation. Diseases related with CD74 include thymic epithelial neoplasm and gastroduodenitis. Amongits related super–pathways are Immune System and Immune response Antigen presentation by MHC class II. In addition CD74 functions as cell surface receptor for the cytokine MIF.
Description:CD74 Human Recombinant produced in E.Coli is a single, non–glycosylated polypeptide chain containing 183 amino acids (73–232 a.a) and having a molecular mass of 20.6kDa.CD74 is fused to a 23 amino acid His–tag at N–terminus & purified by proprietary chromatographic techniques.
Source:Escherichia Coli.
Pack size:20µg
Physical Appearance:Sterile Filtered clear solution.
Formulation:CD74 protein solution (0.5mg/ml) containing 20mM Tris–HCl buffer (pH 8.0), 0.1M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2–4 weeks. Store, frozen at –20°C for longer periods of time. For longterm storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze–thaw cycles.
Purity:Greater than 90.0% as determined by SDS–PAGE.
Biological Activity:N/A
Usage:Assay Genie’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

CD74 Human Recombinant Protein - Protein Information

UniProt Protein Function:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
NCBI Summary:The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Code:P04233
NCBI GenInfo Identifier:20178292
NCBI Gene ID:972
NCBI Accession:P04233.3
UniProt Secondary Accession:P04233,Q14597, Q29832, Q5U0J8, Q8SNA0, Q8WLP6, A8K7R1 B4DNE8, D3DQG3, D3DQG4,
UniProt Related Accession:P04233
Molecular Weight:
NCBI Full Name:HLA class II histocompatibility antigen gamma chain
NCBI Synonym Full Names:CD74 molecule
NCBI Official Symbol:CD74  
NCBI Official Synonym Symbols:II; DHLAG; HLADG; Ia-GAMMA  
NCBI Protein Information:HLA class II histocompatibility antigen gamma chain
UniProt Protein Name:HLA class II histocompatibility antigen gamma chain
UniProt Synonym Protein Names:HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD_antigen: CD74
Protein Family:H-2 class II histocompatibility antigen
UniProt Gene Name:CD74  
UniProt Entry Name:HG2A_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host Species:
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