Human CRNN Recombinant Protein (RPPB3261)
- SKU:
- RPPB3261
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UBG3
Description
| Product Name: | Human CRNN Recombinant Protein |
| Product Code: | RPPB3261 |
| Size: | 25µg |
| Species: | Human |
| Target: | CRNN |
| Synonyms: | SEP53, DRC1, PDRC1, Cornulin, Tumor-related protein, Squamous epithelial heat shock protein 53, 53 kDa squamous epithelial-induced stress protein, 58 kDa heat shock protein, 53 kDa putative calcium-binding protein, CRNN, C1orf10. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | The CRNN solution contains 20mM Tris-HCl pH-8 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATG SAWVSSYDRQ AESQSQERIS PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ AGSHTETVEQ DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST EPGRQEWSST HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG ITARELYSYL RSTKP |
CRNN is part of the "fused gene" family of proteins, which enclose N-terminus EF-hand domains and multiple tandem peptide repeats. CRNN contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. CRNN, also known as SEP53, which participates in the mucosal/epithelial immune response and epidermal differentiation. CRNN is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and discharge of calcium. When CRNN is over expressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.
CRNN Human Recombinant fused to 20 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 515 amino acids (1-495 a.a.) and having a molecular mass of 55.7 kDa. The CRNN is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CRNN: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. Belongs to the S100-fused protein family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cytoplasm; membrane Molecular Function:calcium ion binding Biological Process: cell-cell adhesion; response to heat |
| NCBI Summary: | This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q9UBG3 |
| NCBI GenInfo Identifier: | 7706635 |
| NCBI Gene ID: | 49860 |
| NCBI Accession: | NP_057274.1 |
| UniProt Secondary Accession: | Q9UBG3,Q8N613, B2RE60, |
| UniProt Related Accession: | Q9UBG3 |
| Molecular Weight: | 53,533 Da |
| NCBI Full Name: | cornulin |
| NCBI Synonym Full Names: | cornulin |
| NCBI Official Symbol: | CRNN�� |
| NCBI Official Synonym Symbols: | DRC1; PDRC1; SEP53; C1orf10�� |
| NCBI Protein Information: | cornulin |
| UniProt Protein Name: | Cornulin |
| UniProt Synonym Protein Names: | 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; Squamous epithelial heat shock protein 53; Tumor-related protein |
| Protein Family: | Cornulin |
| UniProt Gene Name: | CRNN�� |
| UniProt Entry Name: | CRNN_HUMAN |
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