| UniProt Protein Function: | INDOL1: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Belongs to the indoleamine 2,3-dioxygenase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.13.11.-Chromosomal Location of Human Ortholog: 8p11.21Cellular Component: cytoplasm; cytosolMolecular Function: metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activityBiological Process: tryptophan catabolic process to kynurenine; tryptophan catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011] |
| UniProt Code: | Q6ZQW0 |
| NCBI GenInfo Identifier: | 215274147 |
| NCBI Gene ID: | 169355 |
| NCBI Accession: | Q6ZQW0.3 |
| UniProt Secondary Accession: | Q6ZQW0,A4UD41 |
| UniProt Related Accession: | Q6ZQW0 |
| Molecular Weight: | |
| NCBI Full Name: | Indoleamine 2,3-dioxygenase 2 |
| NCBI Synonym Full Names: | indoleamine 2,3-dioxygenase 2 |
| NCBI Official Symbol: | IDO2Â Â |
| NCBI Official Synonym Symbols: | INDOL1Â Â |
| NCBI Protein Information: | indoleamine 2,3-dioxygenase 2; IDO-2; indoleamine 2,3-dioxygenase-like 1 protein; indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1; indoleamine-pyrrole 2,3-dioxygenase-like protein 1 |
| UniProt Protein Name: | Indoleamine 2,3-dioxygenase 2 |
| UniProt Synonym Protein Names: | Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1 |
| Protein Family: | Indoleamine 2,3-dioxygenase |
| UniProt Gene Name: | IDO2Â Â |
| UniProt Entry Name: | I23O2_HUMAN |
