| UniProt Protein Function: | LOXL3: a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted; EC 1.4.3.-; Secreted, signal peptide; Oxidoreductase Chromosomal Location of Human Ortholog: 2p13 Cellular Component: extracellular region; nucleus Molecular Function:protein binding Biological Process: epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P58215 |
| NCBI GenInfo Identifier: | 14916616 |
| NCBI Gene ID: | 84695 |
| NCBI Accession: | P58215.1 |
| UniProt Secondary Accession: | P58215,Q2EHP2, Q6IPL7, Q96RS1, D6W5J1, |
| UniProt Related Accession: | P58215 |
| Molecular Weight: | 67,445 Da |
| NCBI Full Name: | Lysyl oxidase homolog 3 |
| NCBI Synonym Full Names: | lysyl oxidase like 3 |
| NCBI Official Symbol: | LOXL3Â Â |
| NCBI Official Synonym Symbols: | LOXLÂ Â |
| NCBI Protein Information: | lysyl oxidase homolog 3 |
| UniProt Protein Name: | Lysyl oxidase homolog 3 |
| UniProt Synonym Protein Names: | Lysyl oxidase-like protein 3 |
| Protein Family: | Lysyl oxidase |
| UniProt Gene Name: | LOXL3Â Â |
| UniProt Entry Name: | LOXL3_HUMAN |
