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Anti-METAP2 Antibody (CAB3465)

SKU:
CAB3465
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MAP2
MNPEP
p67eIF2
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:METAP2 Rabbit mAb
Product Code:CAB3465
Size:20uL, 50uL, 100uL
Synonyms:MAP2, MNPEP, p67eIF2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human METAP2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Rat testis, DU145, HT-1080, NIH/3T3, C6, Mouse testis
Immunogen:A synthesized peptide derived from human METAP2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10988
Uniprot:P50579
Cellular Location:Cytoplasm
Calculated MW:67kDa
Observed MW:67kDa
UniProt Protein Function:Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
NCBI Summary:The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Code:P50579
NCBI GenInfo Identifier:5803092
NCBI Gene ID:10988
NCBI Accession:NP_006829
UniProt Related Accession:P50579
Molecular Weight:53kDa
NCBI Full Name:methionine aminopeptidase 2 isoform 1
NCBI Synonym Full Names:methionyl aminopeptidase 2
NCBI Official Symbol:METAP2  
NCBI Official Synonym Symbols:MAP2; MNPEP; p67eIF2  
NCBI Protein Information:methionine aminopeptidase 2
UniProt Protein Name:Methionine aminopeptidase 2
UniProt Synonym Protein Names:Initiation factor 2-associated 67 kDa glycoproteinUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; p67UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; p67eIF2UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; Peptidase MUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175
UniProt Gene Name:METAP2  

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