Mouse HDAC8 Recombinant Protein (RPPB1802)
- SKU:
- RPPB1802
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q8VH37
- Research Area:
- Enzymes
Description
| Product Name: | Mouse HDAC8 Recombinant Protein |
| Product Code: | RPPB1802 |
| Size: | 5µg |
| Species: | Mouse |
| Target: | HDAC8 |
| Synonyms: | Histone deacetylase 8, HD8, Hdac8. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | HDAC8 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MEMPEEPANS GHSLPPVYIY SPEYVSICDS LVKVPKRASM VHSLIEAYAL HKQMRIVKPK VASMEEMATF HTDAYLQHLQ KVSQEGDEDH PDSIEYGLGY DCPATEGIFD YAAAIGGGTI TAAQCLIDGK CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFD RILYVDLDLH HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDMSDVGLG KGRYYSVNVP IQDGIQDEKY YHICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY VLQWQLATLI LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH RIQQILNYIK GNLKHVVHHH HHH |
Histone deacetylase 8 (HDAC8) is a member of the class 1 of the histone deacetylase/acuc/apha family. HDAC8 is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Histones play a key role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation modifies chromosome structure and affects transcription factor access to DNA.
HDAC8 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 383 amino acids (1-377 a.a.) and having a molecular mass of 42.5kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).HDAC8 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. � � � � � � � � � � � � � � � � � � � �
| UniProt Protein Function: | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8VH37 |
| NCBI GenInfo Identifier: | 29839376 |
| NCBI Gene ID: | 70315 |
| NCBI Accession: | Q8VH37.2 |
| UniProt Secondary Accession: | Q8VH37,Q3V270, Q9D0K6 |
| UniProt Related Accession: | Q8VH37 |
| Molecular Weight: | 28,122 Da |
| NCBI Full Name: | Histone deacetylase 8 |
| NCBI Synonym Full Names: | histone deacetylase 8 |
| NCBI Official Symbol: | Hdac8�� |
| NCBI Official Synonym Symbols: | 2610007D20Rik�� |
| NCBI Protein Information: | histone deacetylase 8 |
| UniProt Protein Name: | Histone deacetylase 8 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | Hdac8�� |
| UniProt Entry Name: |
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