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Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody

SKU:
CABP1400
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
IHC
€139 - €609
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Description

Product Name:Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody
Product Code:CABP1400
Reactivity:Human
Applications:Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC56024
Reactivity:Human
Tested Applications:IHC-P, ELISA
Key Applications:Immunohistochemistry
Recommended Dilution:IHC-P 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Cellular Location:cardiac myofibril, cytosol, sarcomere

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.

Immunogen:A synthetic phosphorylated peptide around S23 & S24 of human Cardiac Troponin I (TNNI3) (NP_000354.4).
Sequence:RRSSN Y
Synonyms:CMH7, RCM1, cTnI, CMD2A, TNNC1, CMD1FF
Calculated MW:24kDa
Observed MW:Refer to figures

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