| UniProt Protein Function: | PILRB: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to plasma membrane Molecular Function:protein binding Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q9UKJ0 |
| NCBI GenInfo Identifier: | 74761987 |
| NCBI Gene ID: | 29990 |
| NCBI Accession: | Q9UKJ0.1 |
| UniProt Secondary Accession: | Q9UKJ0,Q69YF9, Q9HBS0, |
| UniProt Related Accession: | Q9UKJ0 |
| Molecular Weight: | 29,630 Da |
| NCBI Full Name: | Paired immunoglobulin-like type 2 receptor beta |
| NCBI Synonym Full Names: | paired immunoglobin-like type 2 receptor beta |
| NCBI Official Symbol: | PILRBÂ Â |
| NCBI Official Synonym Symbols: | FDFACT1; FDFACT2Â Â |
| NCBI Protein Information: | paired immunoglobulin-like type 2 receptor beta; activating receptor PILR-beta; activating receptor PILRbeta; cell surface receptor FDFACT; cell surface receptor FDFACT1; cell surface receptor FDFACT2; paired immunoglobin-like receptor beta; paired immunoglobulin-like receptor beta |
| UniProt Protein Name: | Paired immunoglobulin-like type 2 receptor beta |
| UniProt Synonym Protein Names: | Activating receptor PILR-beta; Cell surface receptor FDFACT |
| Protein Family: | Paired immunoglobulin-like type 2 receptor |
| UniProt Gene Name: | PILRBÂ Â |
| UniProt Entry Name: | PILRB_HUMAN |
