Recombinant Human IL1F6/IL36A Protein (His Tag) (RPES3627)

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SKU:
RPES3627
€399

Description

ELISA Kit Technical Manual

Recombinant Human IL1F6/IL36A Protein (His Tag)

Background:Interleukin family member 6 (ILF6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. ILF6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin (IL) and plays an important role in the pathophysiology of several diseases. It has been reported that ILF6 and ILF8, in addition to ILF9, activate the pathway leading to NF-kappaB in an ILRrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by ILF6 and ILF8 follows a similar time course to activation by ILbeta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses ILRrp2, all three cytokines signal without further receptor transfection. ILRrp2 antibodies block activation of the pathway leading to NF-kappaB by ILF6, ILF8, and ILF9 in both Jurkat and NCI/ADR-RES cells. Thus ILF6, ILF8, and ILF9 signal through ILRrp2 and ILRAcP.
Name:Recombinant Human IL1F6/IL36A Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES3627
Synonyms:Interleukin-36 Alpha; FIL1 Epsilon; Interleukin Epsilon; IL Epsilon; Interleukin Family Member 6; ILF6; IL36A; FIL1E; IL1E; IL1F6
Species:Human
Expression host:E.coli
Sequence:Lys 6-Phe158
Accession:Q9UHA7
Mol Mass:19.2 kDa
AP Mol Mass:20 kDa
Tag:N-His
Purity:> 99 % as determined by reducing SDS-PAGE.
Endotoxin:Please contact us for more information.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:IL1F6: Belongs to the IL family.
UniProt Protein Details:

Protein type:Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: extracellular region; extracellular space

Molecular Function:cytokine activity; interleukin receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway

NCBI Summary:The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]
UniProt Code:Q9UHA7
NCBI GenInfo Identifier:25008601
NCBI Gene ID:27179
NCBI Accession:Q9UHA7.1
UniProt Secondary Accession:Q9UHA7,Q53SR7, Q5BLR4, Q7RTZ8, B2RAD9,
UniProt Related Accession:Q9UHA7
Molecular Weight:17,684 Da
NCBI Full Name:Interleukin-36 alpha
NCBI Synonym Full Names:interleukin 36, alpha
NCBI Official Symbol:IL36A  
NCBI Official Synonym Symbols:FIL1; FIL1E; IL1F6; ILF6; IL1(EPSILON); FIL1(EPSILON)  
NCBI Protein Information:interleukin-36 alpha
UniProt Protein Name:Interleukin-36 alpha
UniProt Synonym Protein Names:FIL1 epsilon; Interleukin epsilon; IL epsilon; Interleukin family member 6; ILF6
Protein Family:Interleukin
UniProt Gene Name:IL36A  
UniProt Entry Name:IL36A_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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