Human Thioredoxin-2/TXN2 Recombinant Protein (RPES0719)

Product type:
Recombinant Protein
Host species:


ELISA Kit Technical Manual

Recombinant Human Thioredoxin-2/TXN2 Protein (His Tag)

Background:Thioredoxin-2 (TXN2) is a mitochondrial member of the thioredoxin family. Thioredoxin-2 is extensively expressed in adult and fetal tissues. Thioredoxin-2 contains an N-terminal 59 amino acid transit peptide, which is cleaved before translocating to mitochondria. Mitochondrial thioredoxin play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. Thioredoxin-2 could be involved in the resistance to anti-tumor agents and possesses a dithiol-reducing activity. In addition, Thioredoxin-2 is important at low oxidative stress conditions.
Name:Recombinant Human Thioredoxin-2/TXN2 Protein (His Tag)
Assay Genie SKU:RPES0719
Synonyms:Thioredoxin Mitochondrial; MTRX; Mt-Trx; Thioredoxin-2; TXN2; TRX2
Expression host:E.coli
Mol Mass:12.0 kDa
AP Mol Mass:13 kDa
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:TXN2: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. Belongs to the thioredoxin family.
UniProt Protein Details:

Protein type:Oxidoreductase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cell soma; mitochondrion; mitochondrial matrix; dendrite; nucleolus

Molecular Function:peptide-methionine-(S)-S-oxide reductase activity; protein complex binding; protein disulfide oxidoreductase activity; peptide-methionine (R)-S-oxide reductase activity

Biological Process: response to drug; cellular response to nutrient levels; response to reactive oxygen species; cell redox homeostasis; response to hormone stimulus; response to glucose stimulus; response to hypoxia; response to axon injury; response to organic cyclic substance; glycerol ether metabolic process; response to nutrient

NCBI Summary:This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q99757
NCBI GenInfo Identifier:20455529
NCBI Gene ID:25828
NCBI Accession:Q99757.2
UniProt Secondary Accession:Q99757,Q5JZA0, Q6FH60, Q9UH29,
UniProt Related Accession:Q99757
Molecular Weight:
NCBI Full Name:Thioredoxin, mitochondrial
NCBI Synonym Full Names:thioredoxin 2
NCBI Official Symbol:TXN2
NCBI Official Synonym Symbols:MTRX; TRX2; MT-TRX
NCBI Protein Information:thioredoxin, mitochondrial; thioredoxin-2; mitochondrial thioredoxin
UniProt Protein Name:Thioredoxin, mitochondrial
UniProt Synonym Protein Names:Thioredoxin-2
UniProt Gene Name:TXN2
UniProt Entry Name:THIOM_HUMAN