UniProt Protein Function: | AKR1CL2: Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones. Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro). Belongs to the aldo/keto reductase family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.1.1.263 Chromosomal Location of Human Ortholog: 10p15.1 |
NCBI Summary: | The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
UniProt Code: | Q96JD6 |
NCBI GenInfo Identifier: | 269849539 |
NCBI Gene ID: | 83592 |
NCBI Accession: | Q96JD6.2 |
UniProt Secondary Accession: | Q96JD6,Q86Z16, Q86Z17, Q86Z18, Q9BU71, |
UniProt Related Accession: | Q96JD6 |
Molecular Weight: | 25,693 Da |
NCBI Full Name: | 1,5-anhydro-D-fructose reductase |
NCBI Synonym Full Names: | aldo-keto reductase family 1 member E2 |
NCBI Official Symbol: | AKR1E2Â Â |
NCBI Official Synonym Symbols: | hTSP; htAKR; AKRDC1; AKR1CL2; LoopADRÂ Â |
NCBI Protein Information: | 1,5-anhydro-D-fructose reductase |
UniProt Protein Name: | 1,5-anhydro-D-fructose reductase |
UniProt Synonym Protein Names: | Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member E2; LoopADR; Testis-specific protein; hTSP |
Protein Family: | 1,5-anhydro-D-fructose reductase |
UniProt Gene Name: | AKR1E2Â Â |
UniProt Entry Name: | AKCL2_HUMAN |