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Anti-HPN Antibody (CAB6620)

SKU:
CAB6620
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HPN
TMPRSS1
hepsin
$155 - $431
Frequently bought together:

Description

Product Name:HPN Rabbit pAb
Product Code:CAB6620
Size:20uL, 50uL, 100uL
Synonyms:HPN, TMPRSS1, hepsin
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-170 of human HPN (NP_002142.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-170 of human HPN (NP_002142.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RSDQ EPLY PVQV SSAD ARLM VFDK TEGT WRLL CSSR SNAR VAGL SCEE MGFL RALT HSEL DVRT AGAN GTSG FFCV DEGR LPHT QRLL EVIS VCDC PRGR FLAA ICQD CGRR KLPV DRIV GGRD TS
Gene ID:3249
Uniprot:P05981
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:45kDa
Observed MW:Refer to figures
UniProt Protein Function:HPN: Plays an essential role in cell growth and maintenance of cell morphology. Belongs to the peptidase S1 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 3.4.21.106; Protease

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; cell surface; cell soma; integral to plasma membrane; plasma membrane; integral to membrane; intercellular junction

Molecular Function:peptidase activity; calcium-activated potassium channel activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: regulation of cell shape; cholesterol homeostasis; detection of mechanical stimulus involved in sensory perception of sound; proteolysis; positive regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of apoptosis

NCBI Summary:This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Code:P05981
NCBI GenInfo Identifier:123057
NCBI Gene ID:3249
NCBI Accession:P05981.1
UniProt Related Accession:P05981
Molecular Weight:45 kDa
NCBI Full Name:Serine protease hepsin
NCBI Synonym Full Names:hepsin
NCBI Official Symbol:HPN  
NCBI Official Synonym Symbols:TMPRSS1  
NCBI Protein Information:serine protease hepsin
UniProt Protein Name:Serine protease hepsin
UniProt Synonym Protein Names:Transmembrane protease serine 1Cleaved into the following 2 chains:Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain
Protein Family:Histidine-rich metal-binding polypeptide
UniProt Gene Name:HPN  
UniProt Entry Name:HEPS_HUMAN

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